Interruption of the mammillothalamic tract prevents seizures in guinea pigs

Marek A. Mirski, James A. Ferrendelli

Research output: Contribution to journalArticlepeer-review

Abstract

Interruption of the connection between the mammillary bodies and the anterior nucleus of the thalamus in guinea pigs, by discrete bilateral electrolytic lesions of the mammillothalamic tract, resulted in essentially complete protection from the behavioral and electroencephalographic convulsant action and lethal effect of pentylenetetrazol. This result demonstrates that the mammillary bodies and their rostral efferent connections are important for the propagation and perhaps initiation of generalized seizures.

Original languageEnglish (US)
Pages (from-to)72-74
Number of pages3
JournalScience
Volume226
Issue number4670
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

ASJC Scopus subject areas

  • General

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