Interrogating open issues in cancer precision medicine with patient-derived xenografts

Annette T. Byrne; Denis G. Alférez; Frédéric Amant; Daniela Annibali; Joaquín Arribas; Andrew V. Biankin; Alejandra Bruna; Eva Budinská; Carlos Caldas; David K. Chang; Robert B. Clarke; Hans Clevers; George Coukos; Virginie Dangles-Marie; S. Gail Eckhardt; Eva Gonzalez-Suarez; Els Hermans; Manuel Hidalgo; Monika A. Jarzabek; Steven De Jong; Jos Jonkers; Kristel Kemper; Luisa Lanfrancone; Gunhild Mari Mælandsmo; Elisabetta Marangoni; Jean Christophe Marine; Enzo Medico; Jens Henrik Norum; Héctor G. Palmer; Daniel S. Peeper; Pier Giuseppe Pelicci; Alejandro Piris-Gimenez; Sergio Roman-Roman; Oscar M. Rueda; Joan Seoane; Violeta Serra; Laura Soucek; Dominique Vanhecke; Alberto Villanueva; Emilie Vinolo; Andrea Bertotti; Livio Trusolino

doi:10.1038/nrc.2016.140

Interrogating open issues in cancer precision medicine with patient-derived xenografts

Annette T. Byrne, Denis G. Alférez, Frédéric Amant, Daniela Annibali, Joaquín Arribas, Andrew V. Biankin, Alejandra Bruna, Eva Budinská, Carlos Caldas, David K. Chang, Robert B. Clarke, Hans Clevers, George Coukos, Virginie Dangles-Marie, S. Gail Eckhardt, Eva Gonzalez-Suarez, Els Hermans, Manuel Hidalgo, Monika A. Jarzabek, Steven De JongJos Jonkers, Kristel Kemper, Luisa Lanfrancone, Gunhild Mari Mælandsmo, Elisabetta Marangoni, Jean Christophe Marine, Enzo Medico, Jens Henrik Norum, Héctor G. Palmer, Daniel S. Peeper, Pier Giuseppe Pelicci, Alejandro Piris-Gimenez, Sergio Roman-Roman, Oscar M. Rueda, Joan Seoane, Violeta Serra, Laura Soucek, Dominique Vanhecke, Alberto Villanueva, Emilie Vinolo, Andrea Bertotti, Livio Trusolino

Research output: Contribution to journal › Review article › peer-review

294 Scopus citations

Abstract

Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research.

Original language	English (US)
Pages (from-to)	254-268
Number of pages	15
Journal	Nature Reviews Cancer
Volume	17
Issue number	4
DOIs	https://doi.org/10.1038/nrc.2016.140
State	Published - Apr 1 2017
Externally published	Yes

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1038/nrc.2016.140

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Byrne, A. T., Alférez, D. G., Amant, F., Annibali, D., Arribas, J., Biankin, A. V., Bruna, A., Budinská, E., Caldas, C., Chang, D. K., Clarke, R. B., Clevers, H., Coukos, G., Dangles-Marie, V., Gail Eckhardt, S., Gonzalez-Suarez, E., Hermans, E., Hidalgo, M., Jarzabek, M. A., ... Trusolino, L. (2017). Interrogating open issues in cancer precision medicine with patient-derived xenografts. Nature Reviews Cancer, 17(4), 254-268. https://doi.org/10.1038/nrc.2016.140

Byrne, AT, Alférez, DG, Amant, F, Annibali, D, Arribas, J, Biankin, AV, Bruna, A, Budinská, E, Caldas, C, Chang, DK, Clarke, RB, Clevers, H, Coukos, G, Dangles-Marie, V, Gail Eckhardt, S, Gonzalez-Suarez, E, Hermans, E, Hidalgo, M, Jarzabek, MA, De Jong, S, Jonkers, J, Kemper, K, Lanfrancone, L, Mælandsmo, GM, Marangoni, E, Marine, JC, Medico, E, Norum, JH, Palmer, HG, Peeper, DS, Pelicci, PG, Piris-Gimenez, A, Roman-Roman, S, Rueda, OM, Seoane, J, Serra, V, Soucek, L, Vanhecke, D, Villanueva, A, Vinolo, E, Bertotti, A & Trusolino, L 2017, 'Interrogating open issues in cancer precision medicine with patient-derived xenografts', Nature Reviews Cancer, vol. 17, no. 4, pp. 254-268. https://doi.org/10.1038/nrc.2016.140

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abstract = "Patient-derived xenografts (PDXs) have emerged as an important platform to elucidate new treatments and biomarkers in oncology. PDX models are used to address clinically relevant questions, including the contribution of tumour heterogeneity to therapeutic responsiveness, the patterns of cancer evolutionary dynamics during tumour progression and under drug pressure, and the mechanisms of resistance to treatment. The ability of PDX models to predict clinical outcomes is being improved through mouse humanization strategies and the implementation of co-clinical trials, within which patients and PDXs reciprocally inform therapeutic decisions. This Opinion article discusses aspects of PDX modelling that are relevant to these questions and highlights the merits of shared PDX resources to advance cancer medicine from the perspective of EurOPDX, an international initiative devoted to PDX-based research.",

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AU - Arribas, Joaquín

AU - Biankin, Andrew V.

AU - Bruna, Alejandra

AU - Budinská, Eva

AU - Caldas, Carlos

AU - Chang, David K.

AU - Clarke, Robert B.

AU - Clevers, Hans

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AU - Jarzabek, Monika A.

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AU - Mælandsmo, Gunhild Mari

AU - Marangoni, Elisabetta

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AU - Norum, Jens Henrik

AU - Palmer, Héctor G.

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AU - Piris-Gimenez, Alejandro

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AU - Rueda, Oscar M.

AU - Seoane, Joan

AU - Serra, Violeta

AU - Soucek, Laura

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Interrogating open issues in cancer precision medicine with patient-derived xenografts

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