Interrelationships among human chorionic gonadotropin (HCG), 17β-estradiol, progesterone, and estriol in maternal serum: Evidence for an inhibitory effect of the fetal adrenal on secretion of hcg

Ray V. Haning, Leslie Choi, Luis B. Curet, Perry A. Henderson, Amber J. Kiggens, Thomas L. Leifheit, Ronald W. Olson, Mark G. Schwabe, David B. Schwartz, Myrna Traver

Research output: Contribution to journalArticlepeer-review

Abstract

In normal pregnancy, maternal serum hCG reaches a maximum concentration about 8–10 weeks after the last menstrual period and then decreases. To investigate the possibility that this decrease in hCG is produced by an inhibitory effect of steroids originating in the feto-placental unit, hCG, progesterone, 17β-estradiol, and estriol were determined by specific RIAs in 341 serum specimens obtained from 229 different pregnancies. Expressions for predicted hCG as a function of estimated trophoblastic mass and percent predicted hCG were determined to correct for the increase in hCG with increasing trophoblastic mass. The relationships between hCG and progesterone, 17β-estradiol, estriol, or estimated trophoblastic mass were not linear. Expression of the hCG data as percent predicted hCG produced linear relationships between hCG and each of the above steroids. Both hCG itself and percent predicted hCG were shown to have a negative regression on estriol (P < 0.001) and a positive regression on progesterone (P < 0.001), but not on 17β-estradiol (P > 0.05), in a multiple linear regression on all three steroids. These data suggest that hCG production is inhibited by a steroid originating in the fetal adrenal. This inhibitory effect plateaus in late pregnancy, allowing a minor late increase in hCG due to increasing trophoblastic mass.

Original languageEnglish (US)
Pages (from-to)1188-1194
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume56
Issue number6
DOIs
StatePublished - Jun 1983

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

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