Interrelationship and familiality of dyslexia related quantitative measures

G. Schulte-Körne, A. Ziegler, W. Deimel, J. Schumacher, E. Plume, C. Bachmann, A. Kleensang, P. Propping, M. M. Nöthen, A. Warnke, H. Remschmidt, I. R. König

Research output: Contribution to journalArticle

Abstract

Dyslexia is a complex gene-environment disorder with poorly understood etiology that affects about 5% of school-age children. Dyslexia occurs in all languages and is associated with a high level of social and psychological morbidity for the individual and their family; approximately 40-50% have persistent disability into adulthood. The core symptoms are word reading and spelling deficits, but several other cognitive components influence the core phenotype. A broad spectrum of dyslexia related phenotypes, including phonological decoding, phoneme awareness, orthographic processing, short-term memory, rapid naming and basic mathematical abilities, were investigated in large sample of 287 German dyslexia families. We explored the interrelationship between the component phenotypes using correlation and principal component analyses (PCA). In addition, we estimated familiality for phenotypes as well as for the factors suggested by PCA. The correlation between the component phenotypes varied between -0.1 and 0.7. The PCA resulted in three factors: a general dyslexia factor, a speed of processing factor and a mathematical abilities factor. The familiality estimates of single components and factors ranged between 0.25 and 0.63. Instead of analyzing single dyslexia-related components,multivariate analyses including factor analytic approaches may help in the identification of susceptibility genes.

Original languageEnglish (US)
Pages (from-to)160-175
Number of pages16
JournalAnnals of Human Genetics
Volume71
Issue number2
DOIs
StatePublished - Mar 1 2007
Externally publishedYes

Keywords

  • Chromosome 18
  • Dyslexia
  • Familiality
  • Genetics
  • Heritability
  • Linkage
  • Principal component analysis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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  • Cite this

    Schulte-Körne, G., Ziegler, A., Deimel, W., Schumacher, J., Plume, E., Bachmann, C., Kleensang, A., Propping, P., Nöthen, M. M., Warnke, A., Remschmidt, H., & König, I. R. (2007). Interrelationship and familiality of dyslexia related quantitative measures. Annals of Human Genetics, 71(2), 160-175. https://doi.org/10.1111/j.1469-1809.2006.00312.x