Interrelationship among breakdown voltage, latency time and membrane conductance during electroporation of artificial lipid membranes

Vinod Sharma; Leslie Tung; John C. Murphy

Interrelationship among breakdown voltage, latency time and membrane conductance during electroporation of artificial lipid membranes

Vinod Sharma, Leslie Tung, John C. Murphy

School of Medicine

Research output: Contribution to journal › Conference article › peer-review

Abstract

Electroporation of artificial lipid membranes was studied by applying a 10μs, 300-600mV rectangular voltage clamp pulse followed by a ramp of negative slope which decayed to zero in the subsequent 500μs. After the electroporating pulse the membrane conductance begins to increase after a variable time delay (latency time) and shows two distinct phases, a first phase in which conductance increases very rapidly followed by a second slow phase. The inter-relationships between breakdown voltage, latency time and the membrane conductance were investigated in 25 different bilayers.

Original language	English (US)
Pages (from-to)	1177-1178
Number of pages	2
Journal	Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume	16
Issue number	pt 2
State	Published - Dec 1 1994
Event	Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA Duration: Nov 3 1994 → Nov 6 1994

ASJC Scopus subject areas

Signal Processing
Biomedical Engineering
Computer Vision and Pattern Recognition
Health Informatics

Cite this

Interrelationship among breakdown voltage, latency time and membrane conductance during electroporation of artificial lipid membranes. / Sharma, Vinod; Tung, Leslie; Murphy, John C.

In: Annual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings, Vol. 16, No. pt 2, 01.12.1994, p. 1177-1178.

Research output: Contribution to journal › Conference article › peer-review

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N2 - Electroporation of artificial lipid membranes was studied by applying a 10μs, 300-600mV rectangular voltage clamp pulse followed by a ramp of negative slope which decayed to zero in the subsequent 500μs. After the electroporating pulse the membrane conductance begins to increase after a variable time delay (latency time) and shows two distinct phases, a first phase in which conductance increases very rapidly followed by a second slow phase. The inter-relationships between breakdown voltage, latency time and the membrane conductance were investigated in 25 different bilayers.

AB - Electroporation of artificial lipid membranes was studied by applying a 10μs, 300-600mV rectangular voltage clamp pulse followed by a ramp of negative slope which decayed to zero in the subsequent 500μs. After the electroporating pulse the membrane conductance begins to increase after a variable time delay (latency time) and shows two distinct phases, a first phase in which conductance increases very rapidly followed by a second slow phase. The inter-relationships between breakdown voltage, latency time and the membrane conductance were investigated in 25 different bilayers.

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T2 - Proceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2)

Y2 - 3 November 1994 through 6 November 1994

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Interrelationship among breakdown voltage, latency time and membrane conductance during electroporation of artificial lipid membranes

Abstract

ASJC Scopus subject areas

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