Interrelationship among breakdown voltage, latency time and membrane conductance during electroporation of artificial lipid membranes

Vinod Sharma, Leslie Tung, John C. Murphy

Research output: Contribution to journalConference article

Abstract

Electroporation of artificial lipid membranes was studied by applying a 10μs, 300-600mV rectangular voltage clamp pulse followed by a ramp of negative slope which decayed to zero in the subsequent 500μs. After the electroporating pulse the membrane conductance begins to increase after a variable time delay (latency time) and shows two distinct phases, a first phase in which conductance increases very rapidly followed by a second slow phase. The inter-relationships between breakdown voltage, latency time and the membrane conductance were investigated in 25 different bilayers.

Original languageEnglish (US)
Pages (from-to)1177-1178
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume16
Issue numberpt 2
StatePublished - Dec 1 1994
EventProceedings of the 16th Annual International Conference of the IEEE Engineering in Medicine and Biology Society. Part 1 (of 2) - Baltimore, MD, USA
Duration: Nov 3 1994Nov 6 1994

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

Cite this