Interpretation and significance of pathologic findings in transbronchial lung biopsy

A. L A Katzenstein, Frederic B Askin

Research output: Contribution to journalArticle

Abstract

We evaluated the pathologic features and clinical significance of 50 transbronchial lung biopsies from 45 immunosuppressed patients (Group I) and 41 from 39 nonimmunosuppressed patients (Group II). Specific diagnoses were established in only 36% of Group I, and of these two-thirds were infections. Expected inflammatory reactions to infection were absent in most of these immunosuppresed patients. Nonspecific pathologic changes were found in 40%, of which diffuse alveolar damage and interstitial pneumonitis were the most common. The mortality was highest for Group I patients with infections (50%) and with diffuse alveolar damage (56%). In Group II patients specific diagnoses were made in only 7%, although histologic abnormalities were found in an additional 61%. This study emphasizes several important differences which should be considered in evaluating transbronchial lung biopsies from immunosuppressed and nonimmunosuppressed patients. This biopsy procedure is most useful in diagnosing infection in immunosuppressed patients but the histology may be difficult to interpret since the usual inflammatory reactions are often absent. This procedure is also useful in evaluating non-immunosuppressed patients, although open biopsy may be necessary when clinical and pathologic features do not correlate.

Original languageEnglish (US)
Pages (from-to)223-234
Number of pages12
JournalAmerican Journal of Surgical Pathology
Volume4
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Biopsy
Lung
Infection
Interstitial Lung Diseases
Histology
Mortality

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Interpretation and significance of pathologic findings in transbronchial lung biopsy. / Katzenstein, A. L A; Askin, Frederic B.

In: American Journal of Surgical Pathology, Vol. 4, No. 3, 1980, p. 223-234.

Research output: Contribution to journalArticle

@article{764da0834fc6447c97fe77f2f1f9fda3,
title = "Interpretation and significance of pathologic findings in transbronchial lung biopsy",
abstract = "We evaluated the pathologic features and clinical significance of 50 transbronchial lung biopsies from 45 immunosuppressed patients (Group I) and 41 from 39 nonimmunosuppressed patients (Group II). Specific diagnoses were established in only 36{\%} of Group I, and of these two-thirds were infections. Expected inflammatory reactions to infection were absent in most of these immunosuppresed patients. Nonspecific pathologic changes were found in 40{\%}, of which diffuse alveolar damage and interstitial pneumonitis were the most common. The mortality was highest for Group I patients with infections (50{\%}) and with diffuse alveolar damage (56{\%}). In Group II patients specific diagnoses were made in only 7{\%}, although histologic abnormalities were found in an additional 61{\%}. This study emphasizes several important differences which should be considered in evaluating transbronchial lung biopsies from immunosuppressed and nonimmunosuppressed patients. This biopsy procedure is most useful in diagnosing infection in immunosuppressed patients but the histology may be difficult to interpret since the usual inflammatory reactions are often absent. This procedure is also useful in evaluating non-immunosuppressed patients, although open biopsy may be necessary when clinical and pathologic features do not correlate.",
author = "Katzenstein, {A. L A} and Askin, {Frederic B}",
year = "1980",
language = "English (US)",
volume = "4",
pages = "223--234",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Interpretation and significance of pathologic findings in transbronchial lung biopsy

AU - Katzenstein, A. L A

AU - Askin, Frederic B

PY - 1980

Y1 - 1980

N2 - We evaluated the pathologic features and clinical significance of 50 transbronchial lung biopsies from 45 immunosuppressed patients (Group I) and 41 from 39 nonimmunosuppressed patients (Group II). Specific diagnoses were established in only 36% of Group I, and of these two-thirds were infections. Expected inflammatory reactions to infection were absent in most of these immunosuppresed patients. Nonspecific pathologic changes were found in 40%, of which diffuse alveolar damage and interstitial pneumonitis were the most common. The mortality was highest for Group I patients with infections (50%) and with diffuse alveolar damage (56%). In Group II patients specific diagnoses were made in only 7%, although histologic abnormalities were found in an additional 61%. This study emphasizes several important differences which should be considered in evaluating transbronchial lung biopsies from immunosuppressed and nonimmunosuppressed patients. This biopsy procedure is most useful in diagnosing infection in immunosuppressed patients but the histology may be difficult to interpret since the usual inflammatory reactions are often absent. This procedure is also useful in evaluating non-immunosuppressed patients, although open biopsy may be necessary when clinical and pathologic features do not correlate.

AB - We evaluated the pathologic features and clinical significance of 50 transbronchial lung biopsies from 45 immunosuppressed patients (Group I) and 41 from 39 nonimmunosuppressed patients (Group II). Specific diagnoses were established in only 36% of Group I, and of these two-thirds were infections. Expected inflammatory reactions to infection were absent in most of these immunosuppresed patients. Nonspecific pathologic changes were found in 40%, of which diffuse alveolar damage and interstitial pneumonitis were the most common. The mortality was highest for Group I patients with infections (50%) and with diffuse alveolar damage (56%). In Group II patients specific diagnoses were made in only 7%, although histologic abnormalities were found in an additional 61%. This study emphasizes several important differences which should be considered in evaluating transbronchial lung biopsies from immunosuppressed and nonimmunosuppressed patients. This biopsy procedure is most useful in diagnosing infection in immunosuppressed patients but the histology may be difficult to interpret since the usual inflammatory reactions are often absent. This procedure is also useful in evaluating non-immunosuppressed patients, although open biopsy may be necessary when clinical and pathologic features do not correlate.

UR - http://www.scopus.com/inward/record.url?scp=0018836607&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018836607&partnerID=8YFLogxK

M3 - Article

C2 - 7396064

AN - SCOPUS:0018836607

VL - 4

SP - 223

EP - 234

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 3

ER -