International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels

David E. Clapham, Craig Montell, Guenter Schultz, David Julius

Research output: Contribution to journalArticle

Abstract

The transient receptor potential (TRP) proteins are six transmembrane-containing subunits that combine to form cation-selective ion channels. TRP channels are present in yeast, Drosophila, Caenorhabditis elegans, and mammals. They are widely distributed and sense local changes in stimuli ranging from light to temperature and osmolarity. Mammals contain at least 22 distinct genes encoding these ion channels. This summary article presents an overview of the molecular relationships among the TRP channels and a standard nomenclature for them, which is derived from the IUPHAR Compendium of Voltage-Gated Ion Channels. The complete Compendium, including data tables for each member of the TRP channel family, can be found at 〈 http://www.iuphar-db.org/iuphar.ic/〉.

Original languageEnglish (US)
Pages (from-to)591-596
Number of pages6
JournalPharmacological Reviews
Volume55
Issue number4
DOIs
StatePublished - Dec 2003

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Transient Receptor Potential Channels
Ion Channels
Pharmacology
Mammals
Caenorhabditis elegans
Terminology
Osmolar Concentration
Drosophila
Cations
Yeasts
Light
Temperature
Genes
Proteins

ASJC Scopus subject areas

  • Pharmacology

Cite this

International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels : Transient Receptor Potential Channels. / Clapham, David E.; Montell, Craig; Schultz, Guenter; Julius, David.

In: Pharmacological Reviews, Vol. 55, No. 4, 12.2003, p. 591-596.

Research output: Contribution to journalArticle

Clapham, David E. ; Montell, Craig ; Schultz, Guenter ; Julius, David. / International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels : Transient Receptor Potential Channels. In: Pharmacological Reviews. 2003 ; Vol. 55, No. 4. pp. 591-596.
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