Abstract
Background In 2006, WHO published international growth standards for children younger than 5 years, which are now accepted worldwide. In the INTERGROWTH-21st Project, our aim was to complement them by developing international standards for fetuses, newborn infants, and the postnatal growth period of preterm infants. Methods INTERGROWTH-21st is a population-based project that assessed fetal growth and newborn size in eight geographically defi ned urban populations. These groups were selected because most of the health and nutrition needs of mothers were met, adequate antenatal care was provided, and there were no major environmental constraints on growth. As part of the Newborn Cross-Sectional Study (NCSS), a component of INTERGROWTH-21st Project, we measured weight, length, and head circumference in all newborn infants, in addition to collecting data prospectively for pregnancy and the perinatal period. To construct the newborn standards, we selected all pregnancies in women meeting (in addition to the underlying population characteristics) strict individual eligibility criteria for a population at low risk of impaired fetal growth (labelled the NCSS prescriptive subpopulation). Women had a reliable ultrasound estimate of gestational age using crown-rump length before 14 weeks of gestation or biparietal diameter if antenatal care started between 14 weeks and 24 weeks or less of gestation. Newborn anthropometric measures were obtained within 12 h of birth by identically trained anthropometric teams using the same equipment at all sites. Fractional polynomials assuming a skewed t distribution were used to estimate the fi tted centiles. Findings We identifi ed 20 486 (35%) eligible women from the 59 137 pregnant women enrolled in NCSS between May 14, 2009, and Aug 2, 2013. We calculated sex-specifi c observed and smoothed centiles for weight, length, and head circumference for gestational age at birth. The observed and smoothed centiles were almost identical. We present the 3rd, 10th, 50th, 90th, and 97th centile curves according to gestational age and sex. Interpretation We have developed, for routine clinical practice, international anthropometric standards to assess newborn size that are intended to complement the WHO Child Growth Standards and allow comparisons across multiethnic populations. Funding Bill & Melinda Gates Foundation.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 857-868 |
| Number of pages | 12 |
| Journal | The Lancet |
| Volume | 384 |
| Issue number | 9946 |
| State | Published - 2014 |
| Externally published | Yes |
ASJC Scopus subject areas
- Medicine(all)
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International standards for newborn weight, length, and head circumference by gestational age and sex : The Newborn Cross-Sectional Study of the INTERGROWTH-21st Project. / Villar, Jos̈; Ismail, Leila Cheikh; Victora, Cesar G.; Ohuma, Eric O.; Bertino, Enrico; Altman, Doug G.; Lambert, Ann; Papageorghiou, Aris T.; Carvalho, Maria; Jaffer, Yasmin A.; Gravett, Michael G.; Purwar, Manorama; Frederick, Ihunnaya O.; Noble, Alison J.; Pang, Ruyan; Barros, Fernando C.; Chumlea, Cameron; Bhutta, Zulfiqar A.; Kennedy, Stephen H.; Katz, M.; Bhan, M. K.; Garza, C.; Zaidi, S.; Langer, A.; Rothwell, P. M.; Weatherall, D.; Bhutta, Z. A.; Villar, J.; Kennedy, S.; Altman, D. G.; Barros, F. C.; Bertino, E.; Burton, F.; Carvalho, M.; Ismail, L. Cheikh; Chumlea, W. C.; Gravett, M. G.; Er, Y. A Jaff; Lambert, A.; Lumbiganon, P.; Noble, J. A.; Pang, R. Y.; Papageorghiou, A. T.; Purwar, M.; Rivera, J.; Victora, C. G.; Villar, J.; Altman, D. G.; Bhutta, Z. A.; Kennedy, S.; Lambert, A.; Noble, J. A.; Papageorghiou, A. T.; Villar, J.; Kennedy, S.; Lambert, A.; Papageorghiou, A. T.; Shorten, M.; Hoch, L.; Knight, H. E.; Ohuma, E. O.; Cosgrove, C.; Blakey, I.; Altman, D. G.; Ohuma, E. O.; Villar, J.; Altman, D. G.; Roseman, F.; Kunnawar, N.; Gu, S. H.; Wang, J. H.; Wu, M. H.; Domingues, M.; Gilli, P.; Juodvirsiene, L.; Hoch, L.; Musee, N.; Al-Jabri, H.; Waller, S.; Cosgrove, C.; Muninzwa, D.; Ohuma, E. O.; Yellappan, D.; Carter, A.; Reade, D.; Miller, R.; Papageorghiou, A. T.; Salomon, L.; Leston, A.; Mitidieri, A.; Al-Aamri, F.; Paulsene, W.; Sande, J.; Al-Zadjali, W. K S; Batiuk, C.; Bornemeier, S.; Carvalho, M.; Dighe, M.; Gaglioti, P.; Jacinta, N.; Jaiswal, S.; Noble, J. A.; Oas, K.; Oberto, M.; Olearo, E.; Owende, M. G.; Shah, J.; Sohoni, S.; Todros, T.; Venkataraman, M.; Vinayak, S.; Wang, L.; Wilson, D.; Wu, Q. Q.; Zaidi, S.; Zhang, Y.; Chamberlain, P.; Danelon, D.; Sarris, I.; Dhami, J.; Ioannou, C.; Knight, C. L.; Napolitano, R.; Wanyonyi, S.; Pace, C.; Mkrtychyan, V.; Ismail, L. Cheikh; Chumlea, W. C.; Al-Habsi, F.; Bhutta, Z. A.; Carter, A.; Alija, M.; Jimenez-Bustos, J. M.; Kizidio, J.; Puglia, F.; Kunnawar, N.; Liu, H.; Lloyd, S.; Mota, D.; Ochieng, R.; Rossi, C.; Luna, M. Sanchez; Shen, Y. J.; Knight, H. E.; Rocco, D. A.; Frederick, I. O.; Bhutta, Z. A.; Albernaz, E.; Batra, M.; Bhat, B. A.; Bertino, E.; Di Nicola, P.; Giuliani, F.; Rovelli, I.; McCormick, K.; Ochieng, R.; Pang, R. Y.; Paul, V.; Rajan, V.; Wilkinson, A.; Varalda, A.; Eskenazi, B.; Corra, L. A.; Dolk, H.; Golding, J.; Matijasevich, A.; De Wet, T.; Zhang, J. J.; Bradman, A.; Finkton, D.; Burnham, O.; Farhi, F.; Barros, F. C.; Domingues, M.; Fonseca, S.; Leston, A.; Mitidieri, A.; Mota, D.; Sclowitz, I. K.; Da Silveira, M.; Pang, R. Y.; He, Y. P.; Pan, Y.; Shen, Y. J.; Wu, M. H.; Wu, Q. Q.; Wang, J. H.; Yuan, Y.; Zhang, Y.; Purwar, M.; Choudhary, A.; Choudhary, S.; Deshmukh, S.; Dongaonkar, D.; Ketkar, M.; Khedikar, V.; Kunnawar, N.; Mahorkar, C.; Mulik, I.; Saboo, K.; Shembekar, C.; Singh, A.; Taori, V.; Tayade, K.; Somani, A.; Bertino, E.; Di Nicola, P.; Frigerio, M.; Gilli, G.; Gilli, P.; Giolito, M.; Giuliani, F.; Oberto, M.; Occhi, L.; Rossi, C.; Rovelli, I.; Signorile, F.; Stones, T.; Todros, W.; Carvalho, M.; Kizidio, J.; Ochieng, R.; Shah, J.; Vinayak, S.; Musee, N.; Kisiang'ani, C.; Muninzwa, D.; Jaffer, Y. A.; Al-Abri, J.; Al-Abduwani, J.; Al-Habsi, F. M.; Al-Lawatiya, H.; Al-Rashidiya, B.; Al-Zadjali, W. K S; Juangco, F. R.; Venkataraman, M.; Al-Jabri, H.; Yellappan, D.; Kennedy, S.; Papageorghiou, A. T.; Roseman, F.; Lambert, A.; Ohuma, E. O.; Lloyd, S.; Napolitano, R.; Ioannou, C.; Sarris, I.; Gravett, M. G.; Batiuk, C.; Batra, M.; Bornemeier, S.; Dighe, M.; Oas, K.; Paulsene, W.; Wilson, D.; Frederick, I. O.; Andersen, H. F.; Abbott, S. E.; Carter, A. A.; Algren, H.; Rocco, D. A.; Sorensen, T. K.; Enquobahrie, D.; Waller, S.
In: The Lancet, Vol. 384, No. 9946, 2014, p. 857-868.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - International standards for newborn weight, length, and head circumference by gestational age and sex
T2 - The Newborn Cross-Sectional Study of the INTERGROWTH-21st Project
AU - Villar, Jos̈
AU - Ismail, Leila Cheikh
AU - Victora, Cesar G.
AU - Ohuma, Eric O.
AU - Bertino, Enrico
AU - Altman, Doug G.
AU - Lambert, Ann
AU - Papageorghiou, Aris T.
AU - Carvalho, Maria
AU - Jaffer, Yasmin A.
AU - Gravett, Michael G.
AU - Purwar, Manorama
AU - Frederick, Ihunnaya O.
AU - Noble, Alison J.
AU - Pang, Ruyan
AU - Barros, Fernando C.
AU - Chumlea, Cameron
AU - Bhutta, Zulfiqar A.
AU - Kennedy, Stephen H.
AU - Katz, M.
AU - Bhan, M. K.
AU - Garza, C.
AU - Zaidi, S.
AU - Langer, A.
AU - Rothwell, P. M.
AU - Weatherall, D.
AU - Bhutta, Z. A.
AU - Villar, J.
AU - Kennedy, S.
AU - Altman, D. G.
AU - Barros, F. C.
AU - Bertino, E.
AU - Burton, F.
AU - Carvalho, M.
AU - Ismail, L. Cheikh
AU - Chumlea, W. C.
AU - Gravett, M. G.
AU - Er, Y. A Jaff
AU - Lambert, A.
AU - Lumbiganon, P.
AU - Noble, J. A.
AU - Pang, R. Y.
AU - Papageorghiou, A. T.
AU - Purwar, M.
AU - Rivera, J.
AU - Victora, C. G.
AU - Villar, J.
AU - Altman, D. G.
AU - Bhutta, Z. A.
AU - Kennedy, S.
AU - Lambert, A.
AU - Noble, J. A.
AU - Papageorghiou, A. T.
AU - Villar, J.
AU - Kennedy, S.
AU - Lambert, A.
AU - Papageorghiou, A. T.
AU - Shorten, M.
AU - Hoch, L.
AU - Knight, H. E.
AU - Ohuma, E. O.
AU - Cosgrove, C.
AU - Blakey, I.
AU - Altman, D. G.
AU - Ohuma, E. O.
AU - Villar, J.
AU - Altman, D. G.
AU - Roseman, F.
AU - Kunnawar, N.
AU - Gu, S. H.
AU - Wang, J. H.
AU - Wu, M. H.
AU - Domingues, M.
AU - Gilli, P.
AU - Juodvirsiene, L.
AU - Hoch, L.
AU - Musee, N.
AU - Al-Jabri, H.
AU - Waller, S.
AU - Cosgrove, C.
AU - Muninzwa, D.
AU - Ohuma, E. O.
AU - Yellappan, D.
AU - Carter, A.
AU - Reade, D.
AU - Miller, R.
AU - Papageorghiou, A. T.
AU - Salomon, L.
AU - Leston, A.
AU - Mitidieri, A.
AU - Al-Aamri, F.
AU - Paulsene, W.
AU - Sande, J.
AU - Al-Zadjali, W. K S
AU - Batiuk, C.
AU - Bornemeier, S.
AU - Carvalho, M.
AU - Dighe, M.
AU - Gaglioti, P.
AU - Jacinta, N.
AU - Jaiswal, S.
AU - Noble, J. A.
AU - Oas, K.
AU - Oberto, M.
AU - Olearo, E.
AU - Owende, M. G.
AU - Shah, J.
AU - Sohoni, S.
AU - Todros, T.
AU - Venkataraman, M.
AU - Vinayak, S.
AU - Wang, L.
AU - Wilson, D.
AU - Wu, Q. Q.
AU - Zaidi, S.
AU - Zhang, Y.
AU - Chamberlain, P.
AU - Danelon, D.
AU - Sarris, I.
AU - Dhami, J.
AU - Ioannou, C.
AU - Knight, C. L.
AU - Napolitano, R.
AU - Wanyonyi, S.
AU - Pace, C.
AU - Mkrtychyan, V.
AU - Ismail, L. Cheikh
AU - Chumlea, W. C.
AU - Al-Habsi, F.
AU - Bhutta, Z. A.
AU - Carter, A.
AU - Alija, M.
AU - Jimenez-Bustos, J. M.
AU - Kizidio, J.
AU - Puglia, F.
AU - Kunnawar, N.
AU - Liu, H.
AU - Lloyd, S.
AU - Mota, D.
AU - Ochieng, R.
AU - Rossi, C.
AU - Luna, M. Sanchez
AU - Shen, Y. J.
AU - Knight, H. E.
AU - Rocco, D. A.
AU - Frederick, I. O.
AU - Bhutta, Z. A.
AU - Albernaz, E.
AU - Batra, M.
AU - Bhat, B. A.
AU - Bertino, E.
AU - Di Nicola, P.
AU - Giuliani, F.
AU - Rovelli, I.
AU - McCormick, K.
AU - Ochieng, R.
AU - Pang, R. Y.
AU - Paul, V.
AU - Rajan, V.
AU - Wilkinson, A.
AU - Varalda, A.
AU - Eskenazi, B.
AU - Corra, L. A.
AU - Dolk, H.
AU - Golding, J.
AU - Matijasevich, A.
AU - De Wet, T.
AU - Zhang, J. J.
AU - Bradman, A.
AU - Finkton, D.
AU - Burnham, O.
AU - Farhi, F.
AU - Barros, F. C.
AU - Domingues, M.
AU - Fonseca, S.
AU - Leston, A.
AU - Mitidieri, A.
AU - Mota, D.
AU - Sclowitz, I. K.
AU - Da Silveira, M.
AU - Pang, R. Y.
AU - He, Y. P.
AU - Pan, Y.
AU - Shen, Y. J.
AU - Wu, M. H.
AU - Wu, Q. Q.
AU - Wang, J. H.
AU - Yuan, Y.
AU - Zhang, Y.
AU - Purwar, M.
AU - Choudhary, A.
AU - Choudhary, S.
AU - Deshmukh, S.
AU - Dongaonkar, D.
AU - Ketkar, M.
AU - Khedikar, V.
AU - Kunnawar, N.
AU - Mahorkar, C.
AU - Mulik, I.
AU - Saboo, K.
AU - Shembekar, C.
AU - Singh, A.
AU - Taori, V.
AU - Tayade, K.
AU - Somani, A.
AU - Bertino, E.
AU - Di Nicola, P.
AU - Frigerio, M.
AU - Gilli, G.
AU - Gilli, P.
AU - Giolito, M.
AU - Giuliani, F.
AU - Oberto, M.
AU - Occhi, L.
AU - Rossi, C.
AU - Rovelli, I.
AU - Signorile, F.
AU - Stones, T.
AU - Todros, W.
AU - Carvalho, M.
AU - Kizidio, J.
AU - Ochieng, R.
AU - Shah, J.
AU - Vinayak, S.
AU - Musee, N.
AU - Kisiang'ani, C.
AU - Muninzwa, D.
AU - Jaffer, Y. A.
AU - Al-Abri, J.
AU - Al-Abduwani, J.
AU - Al-Habsi, F. M.
AU - Al-Lawatiya, H.
AU - Al-Rashidiya, B.
AU - Al-Zadjali, W. K S
AU - Juangco, F. R.
AU - Venkataraman, M.
AU - Al-Jabri, H.
AU - Yellappan, D.
AU - Kennedy, S.
AU - Papageorghiou, A. T.
AU - Roseman, F.
AU - Lambert, A.
AU - Ohuma, E. O.
AU - Lloyd, S.
AU - Napolitano, R.
AU - Ioannou, C.
AU - Sarris, I.
AU - Gravett, M. G.
AU - Batiuk, C.
AU - Batra, M.
AU - Bornemeier, S.
AU - Dighe, M.
AU - Oas, K.
AU - Paulsene, W.
AU - Wilson, D.
AU - Frederick, I. O.
AU - Andersen, H. F.
AU - Abbott, S. E.
AU - Carter, A. A.
AU - Algren, H.
AU - Rocco, D. A.
AU - Sorensen, T. K.
AU - Enquobahrie, D.
AU - Waller, S.
PY - 2014
Y1 - 2014
N2 - Background In 2006, WHO published international growth standards for children younger than 5 years, which are now accepted worldwide. In the INTERGROWTH-21st Project, our aim was to complement them by developing international standards for fetuses, newborn infants, and the postnatal growth period of preterm infants. Methods INTERGROWTH-21st is a population-based project that assessed fetal growth and newborn size in eight geographically defi ned urban populations. These groups were selected because most of the health and nutrition needs of mothers were met, adequate antenatal care was provided, and there were no major environmental constraints on growth. As part of the Newborn Cross-Sectional Study (NCSS), a component of INTERGROWTH-21st Project, we measured weight, length, and head circumference in all newborn infants, in addition to collecting data prospectively for pregnancy and the perinatal period. To construct the newborn standards, we selected all pregnancies in women meeting (in addition to the underlying population characteristics) strict individual eligibility criteria for a population at low risk of impaired fetal growth (labelled the NCSS prescriptive subpopulation). Women had a reliable ultrasound estimate of gestational age using crown-rump length before 14 weeks of gestation or biparietal diameter if antenatal care started between 14 weeks and 24 weeks or less of gestation. Newborn anthropometric measures were obtained within 12 h of birth by identically trained anthropometric teams using the same equipment at all sites. Fractional polynomials assuming a skewed t distribution were used to estimate the fi tted centiles. Findings We identifi ed 20 486 (35%) eligible women from the 59 137 pregnant women enrolled in NCSS between May 14, 2009, and Aug 2, 2013. We calculated sex-specifi c observed and smoothed centiles for weight, length, and head circumference for gestational age at birth. The observed and smoothed centiles were almost identical. We present the 3rd, 10th, 50th, 90th, and 97th centile curves according to gestational age and sex. Interpretation We have developed, for routine clinical practice, international anthropometric standards to assess newborn size that are intended to complement the WHO Child Growth Standards and allow comparisons across multiethnic populations. Funding Bill & Melinda Gates Foundation.
AB - Background In 2006, WHO published international growth standards for children younger than 5 years, which are now accepted worldwide. In the INTERGROWTH-21st Project, our aim was to complement them by developing international standards for fetuses, newborn infants, and the postnatal growth period of preterm infants. Methods INTERGROWTH-21st is a population-based project that assessed fetal growth and newborn size in eight geographically defi ned urban populations. These groups were selected because most of the health and nutrition needs of mothers were met, adequate antenatal care was provided, and there were no major environmental constraints on growth. As part of the Newborn Cross-Sectional Study (NCSS), a component of INTERGROWTH-21st Project, we measured weight, length, and head circumference in all newborn infants, in addition to collecting data prospectively for pregnancy and the perinatal period. To construct the newborn standards, we selected all pregnancies in women meeting (in addition to the underlying population characteristics) strict individual eligibility criteria for a population at low risk of impaired fetal growth (labelled the NCSS prescriptive subpopulation). Women had a reliable ultrasound estimate of gestational age using crown-rump length before 14 weeks of gestation or biparietal diameter if antenatal care started between 14 weeks and 24 weeks or less of gestation. Newborn anthropometric measures were obtained within 12 h of birth by identically trained anthropometric teams using the same equipment at all sites. Fractional polynomials assuming a skewed t distribution were used to estimate the fi tted centiles. Findings We identifi ed 20 486 (35%) eligible women from the 59 137 pregnant women enrolled in NCSS between May 14, 2009, and Aug 2, 2013. We calculated sex-specifi c observed and smoothed centiles for weight, length, and head circumference for gestational age at birth. The observed and smoothed centiles were almost identical. We present the 3rd, 10th, 50th, 90th, and 97th centile curves according to gestational age and sex. Interpretation We have developed, for routine clinical practice, international anthropometric standards to assess newborn size that are intended to complement the WHO Child Growth Standards and allow comparisons across multiethnic populations. Funding Bill & Melinda Gates Foundation.
UR - http://www.scopus.com/inward/record.url?scp=84907424655&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84907424655&partnerID=8YFLogxK
M3 - Article
C2 - 25209487
AN - SCOPUS:84907424655
VL - 384
SP - 857
EP - 868
JO - The Lancet
JF - The Lancet
SN - 0140-6736
IS - 9946
ER -