International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy

A. T. Papageorghiou, S. H. Kennedy, L. J. Salomon, E. O. Ohuma, L. Cheikh Ismail, F. C. Barros, A. Lambert, M. Carvalho, Y. A. Jaffer, E. Bertino, M. G. Gravett, D. G. Altman, M. Purwar, J. A. Noble, R. Pang, C. G. Victora, Z. A. Bhutta, J. Villar

Research output: Contribution to journalArticle

Abstract

Objectives There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations. The INTERGROWTH-21st Project aimed to produce the first international standards for early fetal size and ultrasound dating of pregnancy based on CRL measurement.

Methods Urban areas in eight geographically diverse countries that met strict eligibility criteria were selected for the prospective, population-based recruitment, between 9+0 and 13+6weeks' gestation, of healthy well-nourished women with singleton pregnancies at low risk of fetal growth impairment. GA was calculated on the basis of a certain last menstrual period, regular menstrual cycle and lack of hormonal medication or breastfeeding in the preceding 2 months. CRL was measured using strict protocols and quality-control measures. All women were followed up throughout pregnancy until delivery and hospital discharge. Cases of neonatal and fetal death, severe pregnancy complications and congenital abnormalities were excluded from.

Results A total of 4607 women were enrolled in the Fetal Growth Longitudinal Study, one of the three main components of the INTERGROWTH-21st Project, of whom 4321 had a live singleton birth in the absence of severe maternal conditions or congenital abnormalities detected by ultrasound or at birth. The CRL was measured in 56 women at

Conclusions We have produced international prescriptive standards for early fetal linear size and ultrasound dating of pregnancy in the first trimester that can be used throughout the world.

Original languageEnglish (US)
Pages (from-to)641-648
Number of pages8
JournalUltrasound in Obstetrics and Gynecology
Volume44
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

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Crown-Rump Length
First Pregnancy Trimester
Pregnancy
Fetal Development
Gestational Age
Fetal Death
Pregnancy Complications
Live Birth
Menstrual Cycle
Breast Feeding
Quality Control
Longitudinal Studies
Mothers
Parturition
Population

Keywords

  • Crown-rump length
  • Dating
  • Gestational age
  • Global health
  • Growth
  • Pregnancy

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine

Cite this

International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy. / Papageorghiou, A. T.; Kennedy, S. H.; Salomon, L. J.; Ohuma, E. O.; Ismail, L. Cheikh; Barros, F. C.; Lambert, A.; Carvalho, M.; Jaffer, Y. A.; Bertino, E.; Gravett, M. G.; Altman, D. G.; Purwar, M.; Noble, J. A.; Pang, R.; Victora, C. G.; Bhutta, Z. A.; Villar, J.

In: Ultrasound in Obstetrics and Gynecology, Vol. 44, No. 6, 01.12.2014, p. 641-648.

Research output: Contribution to journalArticle

Papageorghiou, AT, Kennedy, SH, Salomon, LJ, Ohuma, EO, Ismail, LC, Barros, FC, Lambert, A, Carvalho, M, Jaffer, YA, Bertino, E, Gravett, MG, Altman, DG, Purwar, M, Noble, JA, Pang, R, Victora, CG, Bhutta, ZA & Villar, J 2014, 'International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy', Ultrasound in Obstetrics and Gynecology, vol. 44, no. 6, pp. 641-648. https://doi.org/10.1002/uog.13448
Papageorghiou, A. T. ; Kennedy, S. H. ; Salomon, L. J. ; Ohuma, E. O. ; Ismail, L. Cheikh ; Barros, F. C. ; Lambert, A. ; Carvalho, M. ; Jaffer, Y. A. ; Bertino, E. ; Gravett, M. G. ; Altman, D. G. ; Purwar, M. ; Noble, J. A. ; Pang, R. ; Victora, C. G. ; Bhutta, Z. A. ; Villar, J. / International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy. In: Ultrasound in Obstetrics and Gynecology. 2014 ; Vol. 44, No. 6. pp. 641-648.
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T1 - International standards for early fetal size and pregnancy dating based on ultrasound measurement of crown-rump length in the first trimester of pregnancy

AU - Papageorghiou, A. T.

AU - Kennedy, S. H.

AU - Salomon, L. J.

AU - Ohuma, E. O.

AU - Ismail, L. Cheikh

AU - Barros, F. C.

AU - Lambert, A.

AU - Carvalho, M.

AU - Jaffer, Y. A.

AU - Bertino, E.

AU - Gravett, M. G.

AU - Altman, D. G.

AU - Purwar, M.

AU - Noble, J. A.

AU - Pang, R.

AU - Victora, C. G.

AU - Bhutta, Z. A.

AU - Villar, J.

PY - 2014/12/1

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N2 - Objectives There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations. The INTERGROWTH-21st Project aimed to produce the first international standards for early fetal size and ultrasound dating of pregnancy based on CRL measurement.Methods Urban areas in eight geographically diverse countries that met strict eligibility criteria were selected for the prospective, population-based recruitment, between 9+0 and 13+6weeks' gestation, of healthy well-nourished women with singleton pregnancies at low risk of fetal growth impairment. GA was calculated on the basis of a certain last menstrual period, regular menstrual cycle and lack of hormonal medication or breastfeeding in the preceding 2 months. CRL was measured using strict protocols and quality-control measures. All women were followed up throughout pregnancy until delivery and hospital discharge. Cases of neonatal and fetal death, severe pregnancy complications and congenital abnormalities were excluded from.Results A total of 4607 women were enrolled in the Fetal Growth Longitudinal Study, one of the three main components of the INTERGROWTH-21st Project, of whom 4321 had a live singleton birth in the absence of severe maternal conditions or congenital abnormalities detected by ultrasound or at birth. The CRL was measured in 56 women at Conclusions We have produced international prescriptive standards for early fetal linear size and ultrasound dating of pregnancy in the first trimester that can be used throughout the world.

AB - Objectives There are no international standards for relating fetal crown-rump length (CRL) to gestational age (GA), and most existing charts have considerable methodological limitations. The INTERGROWTH-21st Project aimed to produce the first international standards for early fetal size and ultrasound dating of pregnancy based on CRL measurement.Methods Urban areas in eight geographically diverse countries that met strict eligibility criteria were selected for the prospective, population-based recruitment, between 9+0 and 13+6weeks' gestation, of healthy well-nourished women with singleton pregnancies at low risk of fetal growth impairment. GA was calculated on the basis of a certain last menstrual period, regular menstrual cycle and lack of hormonal medication or breastfeeding in the preceding 2 months. CRL was measured using strict protocols and quality-control measures. All women were followed up throughout pregnancy until delivery and hospital discharge. Cases of neonatal and fetal death, severe pregnancy complications and congenital abnormalities were excluded from.Results A total of 4607 women were enrolled in the Fetal Growth Longitudinal Study, one of the three main components of the INTERGROWTH-21st Project, of whom 4321 had a live singleton birth in the absence of severe maternal conditions or congenital abnormalities detected by ultrasound or at birth. The CRL was measured in 56 women at Conclusions We have produced international prescriptive standards for early fetal linear size and ultrasound dating of pregnancy in the first trimester that can be used throughout the world.

KW - Crown-rump length

KW - Dating

KW - Gestational age

KW - Global health

KW - Growth

KW - Pregnancy

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