International multicentre prospective study on microwave ablation of liver tumours: Preliminary results

David M. Lloyd, Kwan N. Lau, Fenella Welsh, Kit Fai Lee, David J. Sherlock, Michael A. Choti, John B. Martinie, David A. Iannitti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Microwave ablation (MWA) is increasingly utilized in the treatment of hepatic tumours. Promising single-centre reports have demonstrated its safety and efficacy, but this modality has not been studied in a prospective, multicentre study. Methods: Eighteen international centres recorded operative and perioperative data for patients undergoing MWA for tumours of any origin in a voluntary Internet-based database. All patients underwent operative MWA using a 2.45-GHz generator with a 5-mm antenna. Results: Of the 140 patients, 114 (81.4%) were treated with MWA alone and 26 (18.6%) were treated with MWA combined with resection. Multiple tumours were treated with MWA in 40.0% of patients. A total of 299 tumours were treated in these 140 patients. The median size of ablated lesions was 2.5 cm (range: 0.5-9.5 cm). Tumours were treated with a median of one application (range: 1-6 applications) for a median of 4 min (range: 0.5-30.0 min). A power setting of 100 W was used in 78.9% of cases. Major morbidity was 8.3% and in-hospital mortality was 1.9%. Conclusions: These multi-institution data demonstrate rapid ablation time and low morbidity and mortality rates in patients undergoing operative MWA with a high rate of multiple ablations and concomitant hepatic resection. Longterm follow-up will be required to determine the efficacy of MWA relative to other forms of ablative therapy.

Original languageEnglish (US)
Pages (from-to)579-585
Number of pages7
JournalHPB
Volume13
Issue number8
DOIs
StatePublished - Aug 2011

Keywords

  • liver
  • microwave ablation
  • operative

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Fingerprint Dive into the research topics of 'International multicentre prospective study on microwave ablation of liver tumours: Preliminary results'. Together they form a unique fingerprint.

Cite this