International multicentre prospective study on microwave ablation of liver tumours

Preliminary results

David M. Lloyd, Kwan N. Lau, Fenella Welsh, Kit Fai Lee, David J. Sherlock, Michael A. Choti, John B. Martinie, David A. Iannitti

Research output: Contribution to journalArticle

Abstract

Background: Microwave ablation (MWA) is increasingly utilized in the treatment of hepatic tumours. Promising single-centre reports have demonstrated its safety and efficacy, but this modality has not been studied in a prospective, multicentre study. Methods: Eighteen international centres recorded operative and perioperative data for patients undergoing MWA for tumours of any origin in a voluntary Internet-based database. All patients underwent operative MWA using a 2.45-GHz generator with a 5-mm antenna. Results: Of the 140 patients, 114 (81.4%) were treated with MWA alone and 26 (18.6%) were treated with MWA combined with resection. Multiple tumours were treated with MWA in 40.0% of patients. A total of 299 tumours were treated in these 140 patients. The median size of ablated lesions was 2.5 cm (range: 0.5-9.5 cm). Tumours were treated with a median of one application (range: 1-6 applications) for a median of 4 min (range: 0.5-30.0 min). A power setting of 100 W was used in 78.9% of cases. Major morbidity was 8.3% and in-hospital mortality was 1.9%. Conclusions: These multi-institution data demonstrate rapid ablation time and low morbidity and mortality rates in patients undergoing operative MWA with a high rate of multiple ablations and concomitant hepatic resection. Longterm follow-up will be required to determine the efficacy of MWA relative to other forms of ablative therapy.

Original languageEnglish (US)
Pages (from-to)579-585
Number of pages7
JournalHPB
Volume13
Issue number8
DOIs
StatePublished - Aug 2011

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Microwaves
Multicenter Studies
Prospective Studies
Liver
Neoplasms
Morbidity
Hospital Mortality
Internet
Databases
Safety
Mortality
Therapeutics

Keywords

  • liver
  • microwave ablation
  • operative

ASJC Scopus subject areas

  • Gastroenterology
  • Hepatology

Cite this

Lloyd, D. M., Lau, K. N., Welsh, F., Lee, K. F., Sherlock, D. J., Choti, M. A., ... Iannitti, D. A. (2011). International multicentre prospective study on microwave ablation of liver tumours: Preliminary results. HPB, 13(8), 579-585. https://doi.org/10.1111/j.1477-2574.2011.00338.x

International multicentre prospective study on microwave ablation of liver tumours : Preliminary results. / Lloyd, David M.; Lau, Kwan N.; Welsh, Fenella; Lee, Kit Fai; Sherlock, David J.; Choti, Michael A.; Martinie, John B.; Iannitti, David A.

In: HPB, Vol. 13, No. 8, 08.2011, p. 579-585.

Research output: Contribution to journalArticle

Lloyd, DM, Lau, KN, Welsh, F, Lee, KF, Sherlock, DJ, Choti, MA, Martinie, JB & Iannitti, DA 2011, 'International multicentre prospective study on microwave ablation of liver tumours: Preliminary results', HPB, vol. 13, no. 8, pp. 579-585. https://doi.org/10.1111/j.1477-2574.2011.00338.x
Lloyd, David M. ; Lau, Kwan N. ; Welsh, Fenella ; Lee, Kit Fai ; Sherlock, David J. ; Choti, Michael A. ; Martinie, John B. ; Iannitti, David A. / International multicentre prospective study on microwave ablation of liver tumours : Preliminary results. In: HPB. 2011 ; Vol. 13, No. 8. pp. 579-585.
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