International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video)

Mouen A. Khashab, Ahmed A. Messallam, Manabu Onimaru, Ezra N. Teitelbaum, Michael B. Ujiki, Matthew E. Gitelis, Rani J. Modayil, Eric S. Hungness, Stavros N. Stavropoulos, Mohamad H. El Zein, Hironari Shiwaku, Rastislav Kunda, Alessandro Repici, Hitomi Minami, Philip W. Chiu, Jeffrey Ponsky, Vivek Kumbhari, Payal Saxena, Amit P. Maydeo, Haruhiro Inoue

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Abstract

Background Limited data exist on the use of peroral endoscopic myotomy (POEM) for therapy of spastic esophageal disorders (SEDs). Objective To study the efficacy and safety of POEM for the treatment of patients with diffuse esophageal spasm, jackhammer esophagus, or type III (spastic) achalasia. Design Retrospective study. Setting International, multicenter, academic institutions. Patients All patients who underwent POEM for treatment of SEDs refractory to medical therapy at 11 centers were included. Interventions POEM. Main Outcome Measurements Eckardt score and adverse events. Results A total of 73 patients underwent POEM for treatment of SEDs (diffuse esophageal spasm 9, jackhammer esophagus 10, spastic achalasia 54). POEM was successfully completed in all patients, with a mean procedural time of 118 minutes. The mean length of the submucosal tunnel was 19 cm, and the mean myotomy length was 16 cm. A total of 8 adverse events (11%) occurred, with 5 rated as mild, 3 moderate, and 0 severe. The mean length of hospital stay was 3.4 days. There was a significant decrease in Eckardt scores after POEM (6.71 vs 1.13; P =.0001). Overall, clinical response was observed in 93% of patients during a mean follow-up of 234 days. Chest pain significantly improved in 87% of patients who reported chest pain before POEM. Repeat manometry after POEM was available in 44 patients and showed resolution of initial manometric abnormalities in all cases. Limitations Retrospective design and selection bias. Conclusion POEM offers a logical therapeutic modality for patients with SEDs refractory to medical therapy. Results from this international study suggest POEM as an effective and safe platform for these patients.

Original languageEnglish (US)
Pages (from-to)1170-1177
Number of pages8
JournalGastrointestinal endoscopy
Volume81
Issue number5
DOIs
StatePublished - May 1 2015

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Khashab, M. A., Messallam, A. A., Onimaru, M., Teitelbaum, E. N., Ujiki, M. B., Gitelis, M. E., Modayil, R. J., Hungness, E. S., Stavropoulos, S. N., El Zein, M. H., Shiwaku, H., Kunda, R., Repici, A., Minami, H., Chiu, P. W., Ponsky, J., Kumbhari, V., Saxena, P., Maydeo, A. P., & Inoue, H. (2015). International multicenter experience with peroral endoscopic myotomy for the treatment of spastic esophageal disorders refractory to medical therapy (with video). Gastrointestinal endoscopy, 81(5), 1170-1177. https://doi.org/10.1016/j.gie.2014.10.011