International Harmonization of Toxicologic Pathology Nomenclature: An Overview and Review of Basic Principles

Peter C. Mann, John Vahle, Charlotte M. Keenan, Julia F. Baker, Alys E. Bradley, Dawn G. Goodman, Takanori Harada, Ronald Herbert, Wolfgang Kaufmann, Rupert Kellner, Thomas Nolte, Susanne Rittinghausen, Takuji Tanaka

Research output: Contribution to journalArticle

Abstract

The International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice is a global project that is publishing criteria for both proliferative and nonproliferative changes in laboratory animals. This paper presents a set of general suggestions for terminology across systems. These suggestions include the use of diagnostic versus descriptive terms, modifiers, combination terms, and grading systems; and the use of thresholds, synonyms, and terminology for some processes that are common to several organ systems. The purpose of this paper is to help the reader understand some of the basic principles underlying the International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice process.

Original languageEnglish (US)
Pages (from-to)7S-13S
JournalToxicologic pathology
Volume40
Issue number4
DOIs
StatePublished - Jun 2012

Keywords

  • nomenclature
  • rodent pathology
  • tumors

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Toxicology
  • Cell Biology

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    Mann, P. C., Vahle, J., Keenan, C. M., Baker, J. F., Bradley, A. E., Goodman, D. G., Harada, T., Herbert, R., Kaufmann, W., Kellner, R., Nolte, T., Rittinghausen, S., & Tanaka, T. (2012). International Harmonization of Toxicologic Pathology Nomenclature: An Overview and Review of Basic Principles. Toxicologic pathology, 40(4), 7S-13S. https://doi.org/10.1177/0192623312438738