International consensus diagnostic criteria for neuromyelitis optica spectrum disorders

Dean M. Wingerchuk, Brenda Banwell, Jeffrey L. Bennett, Philippe Cabre, William Carroll, Tanuja Chitnis, Jérôme De Seze, Kazuo Fujihara, Benjamin Greenberg, Anu Jacob, Sven Jarius, Marco Lana-Peixoto, Michael Levy, Jack H. Simon, Silvia Tenembaum, Anthony L. Traboulsee, Patrick Waters, Kay E. Wellik, Brian G. Weinshenker

Research output: Contribution to journalArticle

Abstract

Neuromyelitis optica (NMO) is an inflammatory CNS syndrome distinct from multiple sclerosis (MS) that is associated with serum aquaporin-4 immunoglobulin G antibodies (AQP4-IgG). Prior NMO diagnostic criteria required optic nerve and spinal cord involvement but more restricted or more extensive CNS involvement may occur. The International Panel for NMO Diagnosis (IPND) was convened to develop revised diagnostic criteria using systematic literature reviews and electronic surveys to facilitate consensus. The new nomenclature defines the unifying term NMO spectrum disorders (NMOSD), which is stratified further by serologic testing (NMOSD with or without AQP4-IgG). The core clinical characteristics required for patients with NMOSD with AQP4-IgG include clinical syndromes or MRI findings related to optic nerve, spinal cord, area postrema, other brainstem, diencephalic, or cerebral presentations. More stringent clinical criteria, with additional neuroimaging findings, are required for diagnosis of NMOSD without AQP4-IgG or when serologic testing is unavailable. The IPND also proposed validation strategies and achieved consensus on pediatric NMOSD diagnosis and the concepts of monophasic NMOSD and opticospinal MS.

Original languageEnglish (US)
Pages (from-to)177-189
Number of pages13
JournalNeurology
Volume85
Issue number2
DOIs
StatePublished - Jul 1 2015

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Neuromyelitis Optica
Immunoglobulin G
Optic Nerve
Spinal Cord
Aquaporin 4
Area Postrema
Terminology
Neuroimaging
Brain Stem
Multiple Sclerosis
Pediatrics

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Wingerchuk, D. M., Banwell, B., Bennett, J. L., Cabre, P., Carroll, W., Chitnis, T., ... Weinshenker, B. G. (2015). International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology, 85(2), 177-189. https://doi.org/10.1212/WNL.0000000000001729

International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. / Wingerchuk, Dean M.; Banwell, Brenda; Bennett, Jeffrey L.; Cabre, Philippe; Carroll, William; Chitnis, Tanuja; De Seze, Jérôme; Fujihara, Kazuo; Greenberg, Benjamin; Jacob, Anu; Jarius, Sven; Lana-Peixoto, Marco; Levy, Michael; Simon, Jack H.; Tenembaum, Silvia; Traboulsee, Anthony L.; Waters, Patrick; Wellik, Kay E.; Weinshenker, Brian G.

In: Neurology, Vol. 85, No. 2, 01.07.2015, p. 177-189.

Research output: Contribution to journalArticle

Wingerchuk, DM, Banwell, B, Bennett, JL, Cabre, P, Carroll, W, Chitnis, T, De Seze, J, Fujihara, K, Greenberg, B, Jacob, A, Jarius, S, Lana-Peixoto, M, Levy, M, Simon, JH, Tenembaum, S, Traboulsee, AL, Waters, P, Wellik, KE & Weinshenker, BG 2015, 'International consensus diagnostic criteria for neuromyelitis optica spectrum disorders', Neurology, vol. 85, no. 2, pp. 177-189. https://doi.org/10.1212/WNL.0000000000001729
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology. 2015 Jul 1;85(2):177-189. https://doi.org/10.1212/WNL.0000000000001729
Wingerchuk, Dean M. ; Banwell, Brenda ; Bennett, Jeffrey L. ; Cabre, Philippe ; Carroll, William ; Chitnis, Tanuja ; De Seze, Jérôme ; Fujihara, Kazuo ; Greenberg, Benjamin ; Jacob, Anu ; Jarius, Sven ; Lana-Peixoto, Marco ; Levy, Michael ; Simon, Jack H. ; Tenembaum, Silvia ; Traboulsee, Anthony L. ; Waters, Patrick ; Wellik, Kay E. ; Weinshenker, Brian G. / International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. In: Neurology. 2015 ; Vol. 85, No. 2. pp. 177-189.
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