Intermittent fasting attenuates inflammasome activity in ischemic stroke

David Yang Wei Fann, Tomislav Santro, Silvia Manzanero, Alexander Widiapradja, Yi Lin Cheng, Seung Yoon Lee, Prasad Chunduri, Dong Gyu Jo, Alexis M. Stranahan, Mark P. Mattson, Thiruma V. Arumugam

Research output: Contribution to journalArticlepeer-review

Abstract

Recent findings have revealed a novel inflammatory mechanism that contributes to tissue injury in cerebral ischemia mediated by multi-protein complexes termed inflammasomes. Intermittent fasting (IF) can decrease the levels of pro-inflammatory cytokines in the periphery and brain. Here we investigated the impact of IF (16. h of food deprivation daily) for 4. months on NLRP1 and NLRP3 inflammasome activities following cerebral ischemia. Ischemic stroke was induced in C57BL/6J mice by middle cerebral artery occlusion, followed by reperfusion (I/R). IF decreased the activation of NF-κB and MAPK signaling pathways, the expression of NLRP1 and NLRP3 inflammasome proteins, and both IL-1β and IL-18 in the ischemic brain tissue. These findings demonstrate that IF can attenuate the inflammatory response and tissue damage following ischemic stroke by a mechanism involving suppression of NLRP1 and NLRP3 inflammasome activity.

Original languageEnglish (US)
Pages (from-to)114-119
Number of pages6
JournalExperimental Neurology
Volume257
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Inflammasomes
  • Intermittent fasting
  • Ischemic stroke
  • NLRP1
  • NLRP3

ASJC Scopus subject areas

  • Neurology
  • Developmental Neuroscience

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