Intermittent fasting: A "new" historical strategy for controlling seizures?

Research output: Contribution to journalArticle

Abstract

In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

Original languageEnglish (US)
Pages (from-to)275-279
Number of pages5
JournalEpilepsy Research
Volume104
Issue number3
DOIs
StatePublished - May 2013

Fingerprint

Ketogenic Diet
Fasting
Seizures
Hunger
Anticonvulsants
Epilepsy

Keywords

  • Children
  • Intermittent fasting
  • Ketogenic diet
  • Medically intractable epilepsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Intermittent fasting : A "new" historical strategy for controlling seizures? / Hartman, Adam L.; Rubenstein, James; Kossoff, Eric H.

In: Epilepsy Research, Vol. 104, No. 3, 05.2013, p. 275-279.

Research output: Contribution to journalArticle

@article{57887f8a971b46079d4587bafdec7c9d,
title = "Intermittent fasting: A {"}new{"} historical strategy for controlling seizures?",
abstract = "In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.",
keywords = "Children, Intermittent fasting, Ketogenic diet, Medically intractable epilepsy",
author = "Hartman, {Adam L.} and James Rubenstein and Kossoff, {Eric H}",
year = "2013",
month = "5",
doi = "10.1016/j.eplepsyres.2012.10.011",
language = "English (US)",
volume = "104",
pages = "275--279",
journal = "Epilepsy Research",
issn = "0920-1211",
publisher = "Elsevier",
number = "3",

}

TY - JOUR

T1 - Intermittent fasting

T2 - A "new" historical strategy for controlling seizures?

AU - Hartman, Adam L.

AU - Rubenstein, James

AU - Kossoff, Eric H

PY - 2013/5

Y1 - 2013/5

N2 - In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

AB - In antiquity, fasting was a treatment for epilepsy and a rationale for the ketogenic diet (KD). Preclinical data indicate the KD and intermittent fasting do not share identical anticonvulsant mechanisms. We implemented an intermittent fasting regimen in six children with an incomplete response to a KD. Three patients adhered to the combined intermittent fasting/KD regimen for 2 months and four had transient improvement in seizure control, albeit with some hunger-related adverse reactions.

KW - Children

KW - Intermittent fasting

KW - Ketogenic diet

KW - Medically intractable epilepsy

UR - http://www.scopus.com/inward/record.url?scp=84876983403&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876983403&partnerID=8YFLogxK

U2 - 10.1016/j.eplepsyres.2012.10.011

DO - 10.1016/j.eplepsyres.2012.10.011

M3 - Article

C2 - 23206889

AN - SCOPUS:84876983403

VL - 104

SP - 275

EP - 279

JO - Epilepsy Research

JF - Epilepsy Research

SN - 0920-1211

IS - 3

ER -