Abstract
Intermittent balloon occlusion of the coronary sinus was applied to 11 open chest dogs subjected to 3 hours of ligation of the left anterior descending coronary artery followed by 8 to 12 days of reperfusion. Anticoagulants were not given during the reperfusion period. Risk region was assessed by planimetry of autoradiographs made from ventricular slices. Infarct size was equivalent when assessed by planimetry of ventricular slices before and after staining with triphenyltetrazolium chloride. In the seven survivors, 30 ± 8% of the risk region was infarcted. Seven of 11 control dogs survived (p = NS); 75 ± 4% of the risk region was infarcted in the control animals (p <0.01 versus treated survivors). Light microscopic inspection of specimens stained with hematoxylin-eosin confirmed the border between necrotic and preserved myocardium. Thrombus was observed in the coronary sinus in all survivors in the treatment group. These findings confirm earlier short-term studies that demonstrated a potent anti-ischemic effect of intermittent coronary sinus occlusion. At the same time, coronary sinus thrombosis warrants caution in the application of this technique to myocardial ischemia in humans.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1075-1081 |
| Number of pages | 7 |
| Journal | Journal of the American College of Cardiology |
| Volume | 9 |
| Issue number | 5 |
| State | Published - 1987 |
Fingerprint
ASJC Scopus subject areas
- Nursing(all)
Cite this
Intermittent coronary sinus occlusion in dogs : Reduction of infarct size 10 days after reperfusion. / Guerci, A. D.; Ciuffo, A. A.; DiPaula, A. F.; Weisfeldt, Myron.
In: Journal of the American College of Cardiology, Vol. 9, No. 5, 1987, p. 1075-1081.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Intermittent coronary sinus occlusion in dogs
T2 - Reduction of infarct size 10 days after reperfusion
AU - Guerci, A. D.
AU - Ciuffo, A. A.
AU - DiPaula, A. F.
AU - Weisfeldt, Myron
PY - 1987
Y1 - 1987
N2 - Intermittent balloon occlusion of the coronary sinus was applied to 11 open chest dogs subjected to 3 hours of ligation of the left anterior descending coronary artery followed by 8 to 12 days of reperfusion. Anticoagulants were not given during the reperfusion period. Risk region was assessed by planimetry of autoradiographs made from ventricular slices. Infarct size was equivalent when assessed by planimetry of ventricular slices before and after staining with triphenyltetrazolium chloride. In the seven survivors, 30 ± 8% of the risk region was infarcted. Seven of 11 control dogs survived (p = NS); 75 ± 4% of the risk region was infarcted in the control animals (p <0.01 versus treated survivors). Light microscopic inspection of specimens stained with hematoxylin-eosin confirmed the border between necrotic and preserved myocardium. Thrombus was observed in the coronary sinus in all survivors in the treatment group. These findings confirm earlier short-term studies that demonstrated a potent anti-ischemic effect of intermittent coronary sinus occlusion. At the same time, coronary sinus thrombosis warrants caution in the application of this technique to myocardial ischemia in humans.
AB - Intermittent balloon occlusion of the coronary sinus was applied to 11 open chest dogs subjected to 3 hours of ligation of the left anterior descending coronary artery followed by 8 to 12 days of reperfusion. Anticoagulants were not given during the reperfusion period. Risk region was assessed by planimetry of autoradiographs made from ventricular slices. Infarct size was equivalent when assessed by planimetry of ventricular slices before and after staining with triphenyltetrazolium chloride. In the seven survivors, 30 ± 8% of the risk region was infarcted. Seven of 11 control dogs survived (p = NS); 75 ± 4% of the risk region was infarcted in the control animals (p <0.01 versus treated survivors). Light microscopic inspection of specimens stained with hematoxylin-eosin confirmed the border between necrotic and preserved myocardium. Thrombus was observed in the coronary sinus in all survivors in the treatment group. These findings confirm earlier short-term studies that demonstrated a potent anti-ischemic effect of intermittent coronary sinus occlusion. At the same time, coronary sinus thrombosis warrants caution in the application of this technique to myocardial ischemia in humans.
UR - http://www.scopus.com/inward/record.url?scp=0023279292&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023279292&partnerID=8YFLogxK
M3 - Article
C2 - 3571746
AN - SCOPUS:0023279292
VL - 9
SP - 1075
EP - 1081
JO - Journal of the American College of Cardiology
JF - Journal of the American College of Cardiology
SN - 0735-1097
IS - 5
ER -