Intermittent coronary sinus occlusion: Hemodynamic and anti-ischemic effects

Alan D. Guerci, Rafael Beyar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

To determine the anti-ischemic mechanism of intermittent occlusion of the coronary sinus (ICSO), the authors measured coronary arterial and sinus pressure and coronary arterial oxygen saturation before and after coronary artery litigation, with and without ICSO. In dogs, ICSO produced a systolic pressure gradient between the coronary artery and coronary sinus of -20 ± 9 mm Hg (higher venous pressure, p <0.001) and a reduction in the oxygen of 20 ± 13% (p <0.005). In parallel studies the authors constructed a mathematical model of known physiology to test the possibility of venoarterial flow. Predicted and experimental data were similar, indicating a reversal of flow at the microcirculatory level of ischemic regions during ISCO. These data indicate that alternating arteriovenous and venoarterial flow over the ischemic territory is the anti-ischemic mechanism of ICSO.

Original languageEnglish (US)
Title of host publicationIEEE/Engineering in Medicine and Biology Society Annual Conference
PublisherPubl by IEEE
Pages52
Number of pages1
Volume10
Editionpt 1
StatePublished - Nov 1988
EventProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society - New Orleans, LA, USA
Duration: Nov 4 1988Nov 7 1988

Other

OtherProceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society
CityNew Orleans, LA, USA
Period11/4/8811/7/88

Fingerprint

Hemodynamics
Oxygen
Physiology
Pressure gradient
Mathematical models

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Guerci, A. D., & Beyar, R. (1988). Intermittent coronary sinus occlusion: Hemodynamic and anti-ischemic effects. In IEEE/Engineering in Medicine and Biology Society Annual Conference (pt 1 ed., Vol. 10, pp. 52). Publ by IEEE.

Intermittent coronary sinus occlusion : Hemodynamic and anti-ischemic effects. / Guerci, Alan D.; Beyar, Rafael.

IEEE/Engineering in Medicine and Biology Society Annual Conference. Vol. 10 pt 1. ed. Publ by IEEE, 1988. p. 52.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Guerci, AD & Beyar, R 1988, Intermittent coronary sinus occlusion: Hemodynamic and anti-ischemic effects. in IEEE/Engineering in Medicine and Biology Society Annual Conference. pt 1 edn, vol. 10, Publ by IEEE, pp. 52, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, New Orleans, LA, USA, 11/4/88.
Guerci AD, Beyar R. Intermittent coronary sinus occlusion: Hemodynamic and anti-ischemic effects. In IEEE/Engineering in Medicine and Biology Society Annual Conference. pt 1 ed. Vol. 10. Publ by IEEE. 1988. p. 52
Guerci, Alan D. ; Beyar, Rafael. / Intermittent coronary sinus occlusion : Hemodynamic and anti-ischemic effects. IEEE/Engineering in Medicine and Biology Society Annual Conference. Vol. 10 pt 1. ed. Publ by IEEE, 1988. pp. 52
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