TY - JOUR
T1 - Intermittent chemotherapy with isoniazid and streptomycin in Algiers
AU - Chaulet, P.
AU - Larbaoui, D.
AU - Grosset, J.
AU - Abdfrrahim, K.
PY - 1967/6
Y1 - 1967/6
N2 - From 1963 to 1966 the authors studied the effects of twice-weekly intermittent chemotherapy with isoniazid and streptomycin in 114 patients. The dosages of the drugs were 15 mg./kg. (13-17) body weight of isoniazid and 1 g. streptomycin twice weekly, for patients weighing 48 kg. on average. All patients were sputum positive on culture and 98%, had cavitation. Three regimens were successively studied: intermittent chemotherapy from the onset (regimen 1), intermittent chemotherapy after a 'short' initial phase of continuous chemotherapy (regimen 2), intermittent chemotherapy after a 'prolonged' initial phase of continuous chemotherapy (regimen 3). In the initial stage of continuous chemotherapy, patients were given daily isoniazid 10 mg./kg., PAS 10-12 g., streptomycin 1 g. 104 patients were given intermittent treatment for at least 2 months and some of them up to 24 months. Five 'failures' were recorded in regimen 1, two in regimen 2, none in regimen 3. Improvement, i.e. lasfing sputum negativity and x-ray improvement was reported in 93%. An initial phase of continuous chemotherapy seems desirable; its immediate therapeutic value is evident, while the effects of possible primary drug resistance-a relatively frequent occurrence in Algiers-may be prevented. The results achieved in this study contributed to the adoption of intermittent chemotherapy (isoniazid plus streptomycin twice weekly following a phase of continuous treatment of one to three months) as a standard national treatment schedule in Algeria.
AB - From 1963 to 1966 the authors studied the effects of twice-weekly intermittent chemotherapy with isoniazid and streptomycin in 114 patients. The dosages of the drugs were 15 mg./kg. (13-17) body weight of isoniazid and 1 g. streptomycin twice weekly, for patients weighing 48 kg. on average. All patients were sputum positive on culture and 98%, had cavitation. Three regimens were successively studied: intermittent chemotherapy from the onset (regimen 1), intermittent chemotherapy after a 'short' initial phase of continuous chemotherapy (regimen 2), intermittent chemotherapy after a 'prolonged' initial phase of continuous chemotherapy (regimen 3). In the initial stage of continuous chemotherapy, patients were given daily isoniazid 10 mg./kg., PAS 10-12 g., streptomycin 1 g. 104 patients were given intermittent treatment for at least 2 months and some of them up to 24 months. Five 'failures' were recorded in regimen 1, two in regimen 2, none in regimen 3. Improvement, i.e. lasfing sputum negativity and x-ray improvement was reported in 93%. An initial phase of continuous chemotherapy seems desirable; its immediate therapeutic value is evident, while the effects of possible primary drug resistance-a relatively frequent occurrence in Algiers-may be prevented. The results achieved in this study contributed to the adoption of intermittent chemotherapy (isoniazid plus streptomycin twice weekly following a phase of continuous treatment of one to three months) as a standard national treatment schedule in Algeria.
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U2 - 10.1016/S0041-3879(67)80007-2
DO - 10.1016/S0041-3879(67)80007-2
M3 - Article
C2 - 6058030
AN - SCOPUS:0014098144
SN - 0041-3879
VL - 48
SP - 128
EP - 136
JO - Tubercle
JF - Tubercle
IS - 2
ER -