Intermediate phenotypes and genetic mechanisms of psychiatric disorders

Andreas Meyer-Lindenberg, Daniel R. Weinberger

Research output: Contribution to journalReview articlepeer-review


Genes are major contributors to many psychiatric diseases, but their mechanisms of action have long seemed elusive. The intermediate phenotype concept represents a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative, mechanistic aspects of brain function implicated in psychiatric disease. Using imaging genetics as an example, we illustrate recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion.

Original languageEnglish (US)
Pages (from-to)818-827
Number of pages10
JournalNature Reviews Neuroscience
Issue number10
StatePublished - Oct 2006
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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