TY - JOUR
T1 - Intermediate phenotypes and genetic mechanisms of psychiatric disorders
AU - Meyer-Lindenberg, Andreas
AU - Weinberger, Daniel R.
N1 - Funding Information:
This work was supported by the National Institute of Mental Health’s Intramural Research Program. We thank C. Rainey for help with figure preparation.
Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.
PY - 2006/10
Y1 - 2006/10
N2 - Genes are major contributors to many psychiatric diseases, but their mechanisms of action have long seemed elusive. The intermediate phenotype concept represents a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative, mechanistic aspects of brain function implicated in psychiatric disease. Using imaging genetics as an example, we illustrate recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion.
AB - Genes are major contributors to many psychiatric diseases, but their mechanisms of action have long seemed elusive. The intermediate phenotype concept represents a strategy for characterizing the neural systems affected by risk gene variants to elucidate quantitative, mechanistic aspects of brain function implicated in psychiatric disease. Using imaging genetics as an example, we illustrate recent advances, challenges and implications of linking genes to structural and functional variation in brain systems related to cognition and emotion.
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U2 - 10.1038/nrn1993
DO - 10.1038/nrn1993
M3 - Review article
C2 - 16988657
AN - SCOPUS:33748924655
VL - 7
SP - 818
EP - 827
JO - Nature Reviews Neuroscience
JF - Nature Reviews Neuroscience
SN - 1471-003X
IS - 10
ER -