Interleukin 7 generates antitumor cytotoxic t lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy

Douglas L. Jicha, James J. Mulé, Steven A. Rosenberg

Research output: Contribution to journalArticle

Abstract

Interleukin 7 (II:7) is a 25-kD cytokine that was initially described as a pre-B cell growth factor. This cytokine has also been shown to have T cell proliferative and differentiation effects. In this report, we demonstrate that antitumor cytotoxic T lymphocytes (CTL) generated by secondary in vitro sensitization of draining lymph node cells in Ib7 are effective in treating 3-day syngeneic methylcholanthrene (MCA) sarcoma pulmonary metastases in mice. In vivo titrations comparing Ib7 to Ib2 antitumor CTL show that they have equivalent potency in adoptive immunotherapy. IL-7 antitumor CTL generated against MCA sarcomas of weak immunogeneity are also tumor specific in their in vivo efficacy. This study represents the first successful use of a cytokine other than IL-2 for the generation of cells with in vivo efficacy in cellular adoptive transfer.

Original languageEnglish (US)
Pages (from-to)1511-1515
Number of pages5
JournalJournal of Experimental Medicine
Volume174
Issue number6
DOIs
StatePublished - Dec 1 1991

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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