Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy

Douglas L. Jicha, James J. Mulé, Steven A. Rosenberg

Research output: Contribution to journalArticle

Abstract

Interleukin 7 (IL-7) is a 25-kD cytokine that was initially described as a pre-B cell growth factor. This cytokine has also been shown to have T cell proliferative and differentiation effects. In this report, we demonstrate that antitumor cytotoxic T lymphocytes (CTL) generated by secondary in vitro sensitization of draining lymph node cells in IL-7 are effective in treating 3-day syngeneic methylcholanthrene (MCA) sarcoma pulmonary metastases in mice. In vivo titrations comparing IL-7 to IL-2 antitumor CTL show that they have equivalent potency in adoptive immunotherapy. IL-7 antitumor CTL generated against MCA sarcomas of weak immunogeneity are also tumor specific in their in vivo efficacy. This study represents the first successful use of a cytokine other than IL-2 for the generation of cells with in vivo efficacy in cellular adoptive transfer.

Original languageEnglish (US)
Pages (from-to)1511-1515
Number of pages5
JournalJournal of Experimental Medicine
Volume174
Issue number6
StatePublished - Dec 1 1991
Externally publishedYes

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Adoptive Immunotherapy
Interleukin-7
Cytotoxic T-Lymphocytes
Sarcoma
Methylcholanthrene
Cytokines
Interleukin-2
B-Lymphoid Precursor Cells
Adoptive Transfer
Cell Differentiation
Intercellular Signaling Peptides and Proteins
Lymph Nodes
Neoplasm Metastasis
T-Lymphocytes
Lung
Neoplasms

ASJC Scopus subject areas

  • Immunology

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Interleukin 7 generates antitumor cytotoxic T lymphocytes against murine sarcomas with efficacy in cellular adoptive immunotherapy. / Jicha, Douglas L.; Mulé, James J.; Rosenberg, Steven A.

In: Journal of Experimental Medicine, Vol. 174, No. 6, 01.12.1991, p. 1511-1515.

Research output: Contribution to journalArticle

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