TY - JOUR
T1 - Interleukin-7 and interleukin-15 for cancer
AU - Zarogoulidis, Paul
AU - Lampaki, Sofia
AU - Yarmus, Lonny
AU - Kioumis, Ioannis
AU - Pitsiou, Georgia
AU - Katsikogiannis, Nikolaos
AU - Hohenforst-Schmidt, Wolfgang
AU - Li, Qiang
AU - Huang, Haidong
AU - Sakkas, Antonios
AU - Organtzis, John
AU - Sakkas, Leonidas
AU - Mpoukovinas, Ioannis
AU - Tsakiridis, Kosmas
AU - Lazaridis, George
AU - Syrigos, Konstantinos
AU - Zarogoulidis, Konstantinos
PY - 2014
Y1 - 2014
N2 - Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.
AB - Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.
KW - Cancer
KW - IL-15
KW - IL-7
KW - Imunomodulation
UR - http://www.scopus.com/inward/record.url?scp=84920935242&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84920935242&partnerID=8YFLogxK
U2 - 10.7150/jca.10471
DO - 10.7150/jca.10471
M3 - Review article
C2 - 25368677
AN - SCOPUS:84920935242
VL - 5
SP - 765
EP - 773
JO - Journal of Cancer
JF - Journal of Cancer
SN - 1837-9664
IS - 9
ER -