Interleukin-7 and interleukin-15 for cancer

Paul Zarogoulidis, Sofia Lampaki, Lonny Yarmus, Ioannis Kioumis, Georgia Pitsiou, Nikolaos Katsikogiannis, Wolfgang Hohenforst-Schmidt, Qiang Li, Haidong Huang, Antonios Sakkas, John Organtzis, Leonidas Sakkas, Ioannis Mpoukovinas, Kosmas Tsakiridis, George Lazaridis, Konstantinos Syrigos, Konstantinos Zarogoulidis

Research output: Contribution to journalReview article

Abstract

Interleukin 7 and 15 are considered powerful pro-inflammatory cytokines, they have the ability to destabilize chromosomes and induce tumorigenesis. Additionally, they can control malignancy proliferation by influencing the tumor microenvironment and immune system. Immunotherapy has been proposed as a treatment modality for malignancy for over a decade; the exact mechanisms of action and pathways are still under investigation. Interleukin 7 and 15 have been extensively investigated in hematological malignancies since their mode of action influences the stimulation of the immune system in a more direct way than other malignancies such as lung, melanoma, and breast, renal and colorectal cancer.

Original languageEnglish (US)
Pages (from-to)765-773
Number of pages9
JournalJournal of Cancer
Volume5
Issue number9
DOIs
StatePublished - Jan 1 2014

Keywords

  • Cancer
  • IL-15
  • IL-7
  • Imunomodulation

ASJC Scopus subject areas

  • Oncology

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  • Cite this

    Zarogoulidis, P., Lampaki, S., Yarmus, L., Kioumis, I., Pitsiou, G., Katsikogiannis, N., Hohenforst-Schmidt, W., Li, Q., Huang, H., Sakkas, A., Organtzis, J., Sakkas, L., Mpoukovinas, I., Tsakiridis, K., Lazaridis, G., Syrigos, K., & Zarogoulidis, K. (2014). Interleukin-7 and interleukin-15 for cancer. Journal of Cancer, 5(9), 765-773. https://doi.org/10.7150/jca.10471