Interleukin 6 induces human immunodeficiency virus expression in infected monocytic cells alone and in synergy with tumor necrosis factor α by transcriptional and post-transcriptional mechanisms

Guido Poli, Peter Bressler, Audrey Kinter, Elia Duh, William C. Timmer, Arnold Rabson, J. Shawn Justement, Sharilyn Stanley, Anthony S. Fauci

Research output: Contribution to journalArticlepeer-review

Abstract

The immunoregulatory cytokine interleukin 6 (1176) directly upregulates production of human immunodeficiency virus (HIV) in acutely as well as in chronically infected cells of monocytic lineage. In addition, 11,6 synergizes with tumor necrosis factor a (TNF-α) in the induction of latent HIV expression. Unlike TNF-α, upregulation ofviral expression induced by IL6 alone does not occur at the transcriptional level and it is not associated with accumulation of HIV RNA. However, when IM and TNF-α synergistically stimulate HIV production, accumulation of HIV RNA and increased transcription are observed, indicating that IM affects HIV expression at multiple (transcriptional and post-transcriptional) levels.

Original languageEnglish (US)
Pages (from-to)151-158
Number of pages8
JournalJournal of Experimental Medicine
Volume172
Issue number1
DOIs
StatePublished - Jul 1 1990
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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