TY - JOUR
T1 - Interleukin-6 in aging and chronic disease
T2 - A magnificent pathway
AU - Maggio, Marcello
AU - Guralnik, Jack M.
AU - Longo, Dan L.
AU - Ferrucci, Luigi
PY - 2006/6
Y1 - 2006/6
N2 - The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IK-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials.
AB - The human interleukin IL-6 was originally cloned in 1986. In 1993, William Ershler, in his article "IK-6: A Cytokine for Gerontologists," indicated IL-6 as one of the main signaling pathways modulating the complex relationship between aging and chronic morbidity. Over the last 12 years, our understanding of the role of IL-6 in human physiology and pathology has substantially grown, although some of the questions originally posed by Ershler are still debated. In this review, we will focus on IL-6 structure, IL-6 signaling, and trans signaling pathways, and the role of IL-6 in geriatric syndromes and chronic disease. In the final section of this review, we dissect the critical elements of the IL-6 signaling pathway and point out targets for intervention that are targeted by emerging drugs, some still on the horizon and others already being tested in clinical trials.
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M3 - Article
C2 - 16799139
AN - SCOPUS:33745185337
SN - 1079-5006
VL - 61
SP - 575
EP - 584
JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences
IS - 6
ER -