Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension

Lea Ann Matura, Corey E. Ventetuolo, Harold I. Palevsky, David J. Lederer, Evelyn M. Horn, Stephen C. Mathai, Diane Pinder, Christine Archer-Chicko, Emilia Bagiella, Kari E. Roberts, Russell P. Tracy, Paul M. Hassoun, Reda E. Girgis, Steven M. Kawut

Research output: Contribution to journalArticle

Abstract

Rationale: Inflammation is associated with symptoms in many chronic illnesses; however, this link has not been established in pulmonary arterial hypertension. Objectives: The objective of this study was to investigate the association between inflammatory markers and quality of life-related symptoms in patients with pulmonary arterial hypertension. We hypothesized that higher circulating IL-6 and tumor necrosis factor-α levels would be associated with worse quality of life-related symptoms. Methods: We performed a secondary analysis using baseline and 3-month assessments of 62 subjects in a clinical trial of aspirin and simvastatin to determine the association between plasma IL-6 and tumor necrosis factor-α levels and the Medical Outcomes Study Short Form-36 subscales (pain, vitality,mental health). Measurements and Main Results: The mean age was 49.76 13.4 years; 87% were female. Higher IL-6 levels were significantly associated with lower Medical Outcomes Study Short Form-36 subscale scores, indicating worse bodily pain, vitality, and mental health (all P<0.01). Higher tumor necrosis factor-α levels were significantly associated with increased bodily pain, but better mental health scores. Conclusions: IL-6 and tumor necrosis factor-αlevels are associated with certain quality of life domains in patients with pulmonary arterial hypertension.

Original languageEnglish (US)
Pages (from-to)370-375
Number of pages6
JournalAnnals of the American Thoracic Society
Volume12
Issue number3
DOIs
StatePublished - Mar 1 2015

Keywords

  • Fatigue
  • Interleukin-6
  • Pain
  • Pulmonary arterial hypertension
  • Tumor necrosis factor-α

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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    Matura, L. A., Ventetuolo, C. E., Palevsky, H. I., Lederer, D. J., Horn, E. M., Mathai, S. C., Pinder, D., Archer-Chicko, C., Bagiella, E., Roberts, K. E., Tracy, R. P., Hassoun, P. M., Girgis, R. E., & Kawut, S. M. (2015). Interleukin-6 and tumor necrosis factor-α are associated with quality of life-related symptoms in pulmonary arterial hypertension. Annals of the American Thoracic Society, 12(3), 370-375. https://doi.org/10.1513/AnnalsATS.201410-463OC