Abstract
Rationale: Inflammation is associated with symptoms in many chronic illnesses; however, this link has not been established in pulmonary arterial hypertension. Objectives: The objective of this study was to investigate the association between inflammatory markers and quality of life-related symptoms in patients with pulmonary arterial hypertension. We hypothesized that higher circulating IL-6 and tumor necrosis factor-α levels would be associated with worse quality of life-related symptoms. Methods: We performed a secondary analysis using baseline and 3-month assessments of 62 subjects in a clinical trial of aspirin and simvastatin to determine the association between plasma IL-6 and tumor necrosis factor-α levels and the Medical Outcomes Study Short Form-36 subscales (pain, vitality,mental health). Measurements and Main Results: The mean age was 49.76 13.4 years; 87% were female. Higher IL-6 levels were significantly associated with lower Medical Outcomes Study Short Form-36 subscale scores, indicating worse bodily pain, vitality, and mental health (all P<0.01). Higher tumor necrosis factor-α levels were significantly associated with increased bodily pain, but better mental health scores. Conclusions: IL-6 and tumor necrosis factor-αlevels are associated with certain quality of life domains in patients with pulmonary arterial hypertension.
Original language | English (US) |
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Pages (from-to) | 370-375 |
Number of pages | 6 |
Journal | Annals of the American Thoracic Society |
Volume | 12 |
Issue number | 3 |
DOIs | |
State | Published - Mar 1 2015 |
Keywords
- Fatigue
- Interleukin-6
- Pain
- Pulmonary arterial hypertension
- Tumor necrosis factor-α
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine