Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells

J. J. Mule, G. A. Smith, S. A. Rosenberg

Research output: Contribution to journalArticle

Abstract

Interleukin 4 (IL-4) expresses multiple biologic activities, including B cell, mast cell, and T cell stimulation. We showed that the incubation of resting splenocytes from C57BL/6 mice solely in purified native or recombinant mouse IL-4 results in the generation of lymphokine-activated killer (LAK) activity directed against fresh, syngeneic sarcoma cells. The precursor activated by IL-4 expresses surface asialo-GM1. In addition, IL-4 is capable of amplifying the splenic LAK activity induced by recombinant IL-2. The generation, by IL-4, of killer cells with broad antitumor reactivity raises the possibility of using IL-4 alone or in combination with IL-2 in the immunotherapy of cancer in animal models.

Original languageEnglish (US)
Pages (from-to)792-797
Number of pages6
JournalJournal of Experimental Medicine
Volume166
Issue number3
StatePublished - 1987
Externally publishedYes

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Lymphokine-Activated Killer Cells
Interleukin-4
Neoplasms
Lymphokines
Interleukin-2
Inbred C57BL Mouse
Mast Cells
Sarcoma
Immunotherapy
B-Lymphocytes
Animal Models
T-Lymphocytes

ASJC Scopus subject areas

  • Immunology

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Interleukin 4 (B cell stimulatory factor 1) can mediate the induction of lymphokine-activated killer cell activity directed against fresh tumor cells. / Mule, J. J.; Smith, G. A.; Rosenberg, S. A.

In: Journal of Experimental Medicine, Vol. 166, No. 3, 1987, p. 792-797.

Research output: Contribution to journalArticle

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