Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Behçet's disease

Bing Li; Chufang Xie; Xiaomin Lin; Shao Bo Su

doi:10.1016/j.cellimm.2014.06.003

Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Behçet's disease

Bing Li, Chufang Xie, Xiaomin Lin, Shao Bo Su

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.

Original language	English (US)
Pages (from-to)	116-119
Number of pages	4
Journal	Cellular Immunology
Volume	290
Issue number	1
DOIs	https://doi.org/10.1016/j.cellimm.2014.06.003
State	Published - Jul 2014
Externally published	Yes

Keywords

Behçet's disease
Cytokine
IL-28A
PBMCs

ASJC Scopus subject areas

Immunology

Access to Document

10.1016/j.cellimm.2014.06.003

Cite this

@article{7a36e7a9eace47c393ad462ace1fdb7e,

title = "Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Beh{\c c}et's disease",

abstract = "Beh{\c c}et's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.",

keywords = "Beh{\c c}et's disease, Cytokine, IL-28A, PBMCs",

author = "Bing Li and Chufang Xie and Xiaomin Lin and Su, {Shao Bo}",

note = "Funding Information: We are grateful to Hongyan Zhou and Xiangkun Huang for their technical assistance. This work was supported by grants from the Science and Technology Planning Project of Guangdong Province , China (2009B030801170), and the Fundamental Research Funds of State Key Laboratory of Ophthalmology (303060202400439).",

year = "2014",

month = jul,

doi = "10.1016/j.cellimm.2014.06.003",

language = "English (US)",

volume = "290",

pages = "116--119",

journal = "Cellular Immunology",

issn = "0008-8749",

publisher = "Academic Press Inc.",

number = "1",

}

TY - JOUR

T1 - Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Behçet's disease

AU - Li, Bing

AU - Xie, Chufang

AU - Lin, Xiaomin

AU - Su, Shao Bo

N1 - Funding Information: We are grateful to Hongyan Zhou and Xiangkun Huang for their technical assistance. This work was supported by grants from the Science and Technology Planning Project of Guangdong Province , China (2009B030801170), and the Fundamental Research Funds of State Key Laboratory of Ophthalmology (303060202400439).

PY - 2014/7

Y1 - 2014/7

N2 - Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.

AB - Behçet's disease (BD) is an autoimmune disease of unknown etiology. Interleukin-28A (IL-28A) promotes immune responses and may participate in the pathogenesis of autoimmune diseases. To examine the role of IL-28A in the pathogenesis of BD, we measured the expression of IFN-γ and IL-17 by IL-28A-stimulated peripheral blood mononuclear cells (PBMCs) from 19 patients with BD and 16 healthy individuals. We found that IFN-γ and IL-17 were undetectable in the sera from BD patients and control subjects. The mRNA expression and protein production of IFN-γ by IL-28A-stimulated PBMCs from BD patients were significantly increased compared to healthy individuals. No significant difference was observed in the mRNA expression and protein production of IL-17 by IL-28A-stimulated PBMCs between BD patients and normal individuals.

KW - Behçet's disease

KW - Cytokine

KW - IL-28A

KW - PBMCs

UR - http://www.scopus.com/inward/record.url?scp=84903136320&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903136320&partnerID=8YFLogxK

U2 - 10.1016/j.cellimm.2014.06.003

DO - 10.1016/j.cellimm.2014.06.003

M3 - Article

C2 - 24973639

AN - SCOPUS:84903136320

SN - 0008-8749

VL - 290

SP - 116

EP - 119

JO - Cellular Immunology

JF - Cellular Immunology

IS - 1

ER -

Interleukin-28A promotes IFN-γ production by peripheral blood mononuclear cells from patients with Behçet's disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this