Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation

Flavio Vincenti, Robert Kirkman, Susan Light, Ginny Bumgardner, Mark Pescovitz, Philip Halloran, John Neylan, Alan Wilkinson, Henrik Ekberg, Robert Gaston, Lars Backman, James Burdick

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Monoclonal antibodies that block the high-affinity interleukin-2 receptor expressed on alloantigen-reactive T lymphocytes may cause selective immunosuppression. Daclizumab is a genetically engineered human IgG1 monoclonal antibody that binds specifically to the a chain of the interleukin-2 receptor and may thus reduce the risk of rejection after renal transplantation. Methods: We administered daclizumab (1.0 mg per kilogram of body weight) or placebo intravenously before transplantation and once every other week afterward, for a total of five doses, to 260 patients receiving first cadaveric kidney grafts and immunosuppressive therapy with cyclosporine, azathioprine, and prednisone. The patients were followed at regular intervals for 12 months. The primary end point was the incidence of biopsy-confirmed acute rejection within six months after transplantation. Results: Of the 126 patients given daclizumab, 28 (22 percent) had biopsy- confirmed episodes of acute rejection, as compared with 47 of the 134 patients (35 percent) who received placebo (P=0.03). Graft survival at 12 months was 95 percent in the daclizumab-treated patients, as compared with 90 percent in the patients given placebo (P=0.08). The patients given daclizumab did not have any adverse reactions to the drug, and at six months, there were no significant differences between the two groups with respect to infectious complications or cancers. The serum half-life of daclizumab was 20 days, and its administration resulted in prolonged saturation of interleukin-2α receptors on circulating lymphocytes. Conclusions: Daclizumab reduces the frequency of acute rejection in kidney-transplant recipients.

Original languageEnglish (US)
Pages (from-to)161-165
Number of pages5
JournalNew England Journal of Medicine
Volume338
Issue number3
DOIs
StatePublished - Jan 15 1998

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint

Dive into the research topics of 'Interleukin-2-receptor blockade with daclizumab to prevent acute rejection in renal transplantation'. Together they form a unique fingerprint.

Cite this