Interleukin-2 administration causes reversible hemodynamic changes and left ventricular dysfunction similar to those seen in septic shock

F. P. Ognibene, S. A. Rosenberg, M. Lotze, J. Skibber, M. M. Parker, J. H. Shelhamer, J. E. Parrillo

Research output: Contribution to journalArticle

Abstract

Interleukin-2, a lymphocyte product, has well demonstrated antitumor activity in humans. Early clinical studies showed hemodynamic alterations in patients receiving the drug as antitumor immunotherapy. We serially assessed interleukin-2-associated hemodynamic parameters and left ventricular ejection fractions in five patients with neoplastic diseases unresponsive to conventional therapies. By day 4 of therapy, compared with baseline (preinterleukin-2), all patients developed tachycardia (p < 0.01), decreased mean arterial blood pressure (p < 0.05), increased cardiac index (p < 0.05), and decreased systemic vascular resistance (p < 0.01). In addition, left ventricular ejection fraction fell from 58.0 ± 4.7 to 36.4 ± 4.0 percent (0.05 < p < 0.10), which was associated with a trend toward left ventricular dilatation manifested by an increase in left ventricular end-diastolic volume index. Transient renal dysfunction was noted in all five patients, and one developed transient respiratory failure; both types of organ dysfunction recovered to baseline values after cessation of immunotherapy. Thus, interleukin-2 induces multiple reversible cardiovascular abnormalities that are similar to the hemodynamic manifestations of human septic shock.

Original languageEnglish (US)
Pages (from-to)750-754
Number of pages5
JournalCHEST
Volume94
Issue number4
DOIs
StatePublished - Jan 1 1988

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

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    Ognibene, F. P., Rosenberg, S. A., Lotze, M., Skibber, J., Parker, M. M., Shelhamer, J. H., & Parrillo, J. E. (1988). Interleukin-2 administration causes reversible hemodynamic changes and left ventricular dysfunction similar to those seen in septic shock. CHEST, 94(4), 750-754. https://doi.org/10.1378/chest.94.4.750