Interleukin-18 has antipermeablity and antiangiogenic activities in the eye: Reciprocal suppression with VEGF

Jikui Shen, David F. Choy, Tsunehiko Yoshida, Takeshi Iwase, Gulnar Hafiz, Bing Xie, Sean F. Hackett, Joseph R. Arron, Peter A. Campochiaro

Research output: Contribution to journalArticle

Abstract

Interleukin-18 (IL-18) is increased along with IL-1β by activation of the inflammasome and has been implicated in inflammatory and autoimmune diseases, but its role in the eye is uncertain. In patients with macular edema due to retinal vein occlusion, intraocular IL-18 levels increased significantly (P

Original languageEnglish (US)
Pages (from-to)974-983
Number of pages10
JournalJournal of Cellular Physiology
Volume229
Issue number8
DOIs
StatePublished - 2014

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Interleukin-18
Vascular Endothelial Growth Factor A
Inflammasomes
Retinal Vein Occlusion
Macular Edema
Interleukin-1
Autoimmune Diseases
Chemical activation

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology
  • Physiology

Cite this

Interleukin-18 has antipermeablity and antiangiogenic activities in the eye : Reciprocal suppression with VEGF. / Shen, Jikui; Choy, David F.; Yoshida, Tsunehiko; Iwase, Takeshi; Hafiz, Gulnar; Xie, Bing; Hackett, Sean F.; Arron, Joseph R.; Campochiaro, Peter A.

In: Journal of Cellular Physiology, Vol. 229, No. 8, 2014, p. 974-983.

Research output: Contribution to journalArticle

Shen, Jikui ; Choy, David F. ; Yoshida, Tsunehiko ; Iwase, Takeshi ; Hafiz, Gulnar ; Xie, Bing ; Hackett, Sean F. ; Arron, Joseph R. ; Campochiaro, Peter A. / Interleukin-18 has antipermeablity and antiangiogenic activities in the eye : Reciprocal suppression with VEGF. In: Journal of Cellular Physiology. 2014 ; Vol. 229, No. 8. pp. 974-983.
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