@article{f62efc576cf442f7bbaaeb5f8b031e21,
title = "Interleukin-18 and tumor necrosis factor-α are elevated in solid organ transplant recipients with possible cytomegalovirus end-organ disease",
abstract = "End-organ cytomegalovirus (CMV) disease can be life threatening to solid organ transplant recipients. Diagnosis is often complicated by variation in amount of CMV DNA in plasma and the need for an invasive procedure to obtain a biopsy of the suspected affected organ, which can delay recognition and treatment. Several inflammatory cytokines are elevated in CMV disease, and the purpose of this study was to determine if they could be used to distinguish solid organ transplant recipients with CMV DNAemia alone from those with possible end-organ CMV disease. We found that regardless of pre-transplant CMV serostatus, plasma interleukin (IL)-18, tumor necrosis factor-α (TNF-α), and amount of CMV DNA in plasma were increased in possible end-organ CMV disease, with elevated IL-18 associated with increased odds of possible end-organ CMV disease even after adjusting for amount of CMV DNA. These findings highlight IL-18 and TNF-α as potential non-invasive markers of possible end-organ CMV disease regardless of transplanted organ or serostatus in solid organ transplant recipients.",
keywords = "cytokines, cytomegalovirus, end-organ disease",
author = "Karaba, {Andrew H.} and Alexis Figueroa and Werbel, {William A.} and Dioverti, {Maria Veronica} and Steinke, {Seema Mehta} and Ray, {Stuart C.} and Cox, {Andrea L.} and Avery, {Robin K.}",
note = "Funding Information: This work was supported by a grant from the Physician Scientist Training Program at Johns Hopkins University (Andrew H. Karaba). Andrew H. Karaba was also supported by the National Institutes of Health T32 AI007291-27. Alexis Figueroa was supported, in part, by grant D18HP29037 from the U.S. Health Resources and Services Administration, Bureau of Health Workforce, Health Careers Opportunity Program. William A. Werbel is supported by a grant from the Transplantation and Immunology Research Network of the American Society of Transplantation (gSAN-201C0WW). The authors thank Nicholas Cox and Carter Gray for their assistance with sample recovery. We also thank Karen Carroll, Michael Forman, and Heba Mostafa in the Clinical Microbiology Laboratory at Johns Hopkins and the Core for Clinical Research Data Acquisition of the Institute for Clinical and Translational Research at Johns Hopkins for their assistance in identifying and retrieving samples. Funding Information: This work was supported by a grant from the Physician Scientist Training Program at Johns Hopkins University (Andrew H. Karaba). Andrew H. Karaba was also supported by the National Institutes of Health T32 AI007291‐27. Alexis Figueroa was supported, in part, by grant D18HP29037 from the U.S. Health Resources and Services Administration, Bureau of Health Workforce, Health Careers Opportunity Program. William A. Werbel is supported by a grant from the Transplantation and Immunology Research Network of the American Society of Transplantation (gSAN‐201C0WW). The authors thank Nicholas Cox and Carter Gray for their assistance with sample recovery. We also thank Karen Carroll, Michael Forman, and Heba Mostafa in the Clinical Microbiology Laboratory at Johns Hopkins and the Core for Clinical Research Data Acquisition of the Institute for Clinical and Translational Research at Johns Hopkins for their assistance in identifying and retrieving samples. Publisher Copyright: {\textcopyright} 2021 The Authors. Transplant Infectious Disease published by Wiley Periodicals LLC",
year = "2021",
month = aug,
doi = "10.1111/tid.13682",
language = "English (US)",
volume = "23",
journal = "Transplant Infectious Disease",
issn = "1398-2273",
publisher = "Wiley-Blackwell",
number = "4",
}