Abstract
We investigated the effects of human interleukin 10 (IL-10) on the antibacterial and antifungal activities of human neutrophils (PMNs) against Staphylococcus aureus and Candida albicans. Incubation of PMNs from healthy volunteers with 20-100 ng/ml of IL-10 at 37°C for 1 h suppressed phagocytosis of serum-opsonized S. aureus (P = 0.02) and blastoconidia of C. albicans (P < 0.01). In contrast, 2-100 ng/ml of IL-10 had no effect on superoxide anion production upon stimulation with phorbol myristate acetate, N-formylmethionyl leucyl phenylalanine, C. albicans blastoconidia or pseudohyphae; neither did it significantly affect conidiocidal or bactericidal activities of PMNs. However, 20-100 ng/ml of IL-10 significantly decreased PMN-induced damage of C. albicans pseudohyphae (P = 0.008). The suppression of phagocytic activity of PMNs against S. aureus and blastoconidia of C. albicans as well as the impairment of PMN-induced hyphal damage may have important implications for understanding the immunosuppressive profile of IL-10 in clinical usage.
Original language | English (US) |
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Pages (from-to) | 379-387 |
Number of pages | 9 |
Journal | Cytokine |
Volume | 12 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2000 |
Externally published | Yes |
Keywords
- Candida albicans
- Interleukin 10
- Neutrophil
- Staphylococcus aureus
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Biochemistry
- Molecular Biology
- Hematology