Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons: The InCHIANTI Study

Yuri Milaneschi, Anna Maria Corsi, Brenda W. Penninx, Stefania Bandinelli, Jack M. Guralnik, Luigi Ferrucci

Research output: Contribution to journalArticle

Abstract

Background: We test the hypothesis that in older persons higher plasma levels of inflammatory markers predict the development of depressive symptoms during a 6-year follow-up. Method: This study is part of the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) study, a prospective population-based study of older persons. The sample consisted of 991 participants, ages 65 years and older. Serum levels of C-reactive protein, interleukin (IL)-1β, IL-1 receptor antagonist (ra), tumor necrosis factor-α, IL-6, IL-6 receptor, and IL-18 were measured. Depressive symptoms were assessed at baseline and at the 3- and 6-year follow-ups with the Center for Epidemiological Studies-Depression Scale (CES-D). Depressed mood was defined as CES-D > 20. Potential confounders were baseline variables related to sociodemographic, somatic health, and functional status. Results: At baseline, IL-1ra levels were significantly higher (p = .004) in depressed compared with nondepressed participants. After adjustment for confounders, among subjects free of depression at baseline, those in the third and fourth IL-1ra quartiles compared with those in the lowest quartile had, respectively, a 2.32-fold (95% confidence interval: 1.21-4.42, p = .01) and 2.78-fold (95% confidence interval: 1.47-5.26, p = .002) higher risk of developing depressed mood during a 6-year follow-up. Conclusions: In old age, persons with high plasma levels of IL1-ra had a higher risk of developing depressive symptoms over time. These findings suggest a potential causal role for inflammation in the development of depressive symptoms in older persons.

Original languageEnglish (US)
Pages (from-to)973-978
Number of pages6
JournalBiological Psychiatry
Volume65
Issue number11
DOIs
StatePublished - Jun 1 2009
Externally publishedYes

Fingerprint

Interleukin-1 Receptors
Depression
Interleukins
Epidemiologic Studies
Confidence Intervals
Interleukin-6 Receptors
Interleukin-18
Interleukin-1
C-Reactive Protein
Health Status
Interleukin-6
Tumor Necrosis Factor-alpha
Prospective Studies
Inflammation
Serum
Population

Keywords

  • Aging
  • cytokines
  • depression
  • inflammation

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Milaneschi, Y., Corsi, A. M., Penninx, B. W., Bandinelli, S., Guralnik, J. M., & Ferrucci, L. (2009). Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons: The InCHIANTI Study. Biological Psychiatry, 65(11), 973-978. https://doi.org/10.1016/j.biopsych.2008.11.011

Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons : The InCHIANTI Study. / Milaneschi, Yuri; Corsi, Anna Maria; Penninx, Brenda W.; Bandinelli, Stefania; Guralnik, Jack M.; Ferrucci, Luigi.

In: Biological Psychiatry, Vol. 65, No. 11, 01.06.2009, p. 973-978.

Research output: Contribution to journalArticle

Milaneschi, Y, Corsi, AM, Penninx, BW, Bandinelli, S, Guralnik, JM & Ferrucci, L 2009, 'Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons: The InCHIANTI Study', Biological Psychiatry, vol. 65, no. 11, pp. 973-978. https://doi.org/10.1016/j.biopsych.2008.11.011
Milaneschi, Yuri ; Corsi, Anna Maria ; Penninx, Brenda W. ; Bandinelli, Stefania ; Guralnik, Jack M. ; Ferrucci, Luigi. / Interleukin-1 Receptor Antagonist and Incident Depressive Symptoms Over 6 Years in Older Persons : The InCHIANTI Study. In: Biological Psychiatry. 2009 ; Vol. 65, No. 11. pp. 973-978.
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abstract = "Background: We test the hypothesis that in older persons higher plasma levels of inflammatory markers predict the development of depressive symptoms during a 6-year follow-up. Method: This study is part of the InCHIANTI (Invecchiare in Chianti, aging in the Chianti area) study, a prospective population-based study of older persons. The sample consisted of 991 participants, ages 65 years and older. Serum levels of C-reactive protein, interleukin (IL)-1β, IL-1 receptor antagonist (ra), tumor necrosis factor-α, IL-6, IL-6 receptor, and IL-18 were measured. Depressive symptoms were assessed at baseline and at the 3- and 6-year follow-ups with the Center for Epidemiological Studies-Depression Scale (CES-D). Depressed mood was defined as CES-D > 20. Potential confounders were baseline variables related to sociodemographic, somatic health, and functional status. Results: At baseline, IL-1ra levels were significantly higher (p = .004) in depressed compared with nondepressed participants. After adjustment for confounders, among subjects free of depression at baseline, those in the third and fourth IL-1ra quartiles compared with those in the lowest quartile had, respectively, a 2.32-fold (95{\%} confidence interval: 1.21-4.42, p = .01) and 2.78-fold (95{\%} confidence interval: 1.47-5.26, p = .002) higher risk of developing depressed mood during a 6-year follow-up. Conclusions: In old age, persons with high plasma levels of IL1-ra had a higher risk of developing depressive symptoms over time. These findings suggest a potential causal role for inflammation in the development of depressive symptoms in older persons.",
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