Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice

James R. Lane, David A. Neumann, Anne Lafond-Walker, Ahvie Herskowitz, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

We have previously demonstrated that bacterial lipopolysaccharide (LPS) is capable of promoting Coxsackie B3 (CB3)-induced myocarditis in genetically resistant B10.A mice. Because LPS is known to increase production of various cytokines, we tested CB3-infected, LPS-treated mice for the presence of interleukin 1 (IL-1) and tumor necrosis factor (TNF). We found significantly increased amounts of both cytokines in the sera of CB3/LPS-treated mice compared with animals treated only with LPS. We also found immunohistochemical evidence for local production of these cytokines in the cardiac tissue of CB3/LPS-treated mice. Treatment with IL-1 or TNF alone promoted CB3-induced autoimmune myocarditis in resistant B10. A mice. Myocarditis was also observed when uninfected mice were immunized with syngeneic heart extract in the presence of IL-1 or TNF.

Original languageEnglish (US)
Pages (from-to)1123-1129
Number of pages7
JournalJournal of Experimental Medicine
Volume175
Issue number4
StatePublished - Apr 1 1992

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Myocarditis
Interleukin-1
Lipopolysaccharides
Tumor Necrosis Factor-alpha
Cytokines
Serum

ASJC Scopus subject areas

  • Immunology

Cite this

Lane, J. R., Neumann, D. A., Lafond-Walker, A., Herskowitz, A., & Rose, N. R. (1992). Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice. Journal of Experimental Medicine, 175(4), 1123-1129.

Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice. / Lane, James R.; Neumann, David A.; Lafond-Walker, Anne; Herskowitz, Ahvie; Rose, Noel R.

In: Journal of Experimental Medicine, Vol. 175, No. 4, 01.04.1992, p. 1123-1129.

Research output: Contribution to journalArticle

Lane, JR, Neumann, DA, Lafond-Walker, A, Herskowitz, A & Rose, NR 1992, 'Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice', Journal of Experimental Medicine, vol. 175, no. 4, pp. 1123-1129.
Lane JR, Neumann DA, Lafond-Walker A, Herskowitz A, Rose NR. Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice. Journal of Experimental Medicine. 1992 Apr 1;175(4):1123-1129.
Lane, James R. ; Neumann, David A. ; Lafond-Walker, Anne ; Herskowitz, Ahvie ; Rose, Noel R. / Interleukin 1 or tumor necrosis factor can promote coxsackie B3-induced myocarditis in resistant B10.A mice. In: Journal of Experimental Medicine. 1992 ; Vol. 175, No. 4. pp. 1123-1129.
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