TY - JOUR
T1 - Interleukin‐1, Interleukin‐2, Interleukin‐4, Interleukin‐6, Tumor Necrosis Factor α, and Interferon‐γ Levels in Sera from Patients With Scleroderma
AU - Needleman, Barbara White
AU - Wigley, Fredrick M.
AU - Stair, Richard W.
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1992/1
Y1 - 1992/1
N2 - Objective. To determine whether interleukin‐lα (IL‐1α), IL‐1β, IL‐2, IL‐4, interferon‐γ (IFNγ), IL‐6, and tumor necrosis factor α (TNFα) are detected more frequently in sera from scleroderma patients than in sera from controls. Methods. Serum concentrations of these cytokines were measured in 78 scleroderma patients and 73 controls, using enzyme‐linked immunosorbent assay, radioimmunoassay, and bioassay techniques. Results. IL‐2, IL‐4, and IL‐6 were each detected more frequently in sera from scleroderma patients than in sera from controls. TNFα and IL‐1α were found with equal frequency in patient and control sera. IL‐1β and IFNγ were not detected in any sera. Conclusion. IL‐2, IL‐4, and IL‐6 may be among the cytokines that contribute to the disease process in scleroderma patients. To our knowledge, this is the first report of elevated serum IL‐4 levels in human disease.
AB - Objective. To determine whether interleukin‐lα (IL‐1α), IL‐1β, IL‐2, IL‐4, interferon‐γ (IFNγ), IL‐6, and tumor necrosis factor α (TNFα) are detected more frequently in sera from scleroderma patients than in sera from controls. Methods. Serum concentrations of these cytokines were measured in 78 scleroderma patients and 73 controls, using enzyme‐linked immunosorbent assay, radioimmunoassay, and bioassay techniques. Results. IL‐2, IL‐4, and IL‐6 were each detected more frequently in sera from scleroderma patients than in sera from controls. TNFα and IL‐1α were found with equal frequency in patient and control sera. IL‐1β and IFNγ were not detected in any sera. Conclusion. IL‐2, IL‐4, and IL‐6 may be among the cytokines that contribute to the disease process in scleroderma patients. To our knowledge, this is the first report of elevated serum IL‐4 levels in human disease.
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U2 - 10.1002/art.1780350111
DO - 10.1002/art.1780350111
M3 - Article
C2 - 1731816
AN - SCOPUS:0026601232
SN - 0004-3591
VL - 35
SP - 67
EP - 72
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 1
ER -