Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes

D. J. McConkey, P. Hartzell, S. C. Chow, S. Orrenius, M. Jondal

Research output: Contribution to journalArticlepeer-review

Abstract

T Cell receptor signaling has been implicated in an intrathymic process of cell selection in which potentially harmful autoreactive precursors are deleted before they emigrate to the periphery. Recent work has shown that immature thymocytes undergo apoptosis, or programmed cell death, upon stimulation via the T cell antigen receptor, and it has been suggested that this mechanism may mediate deletion of the self-reactive clones during T cell development. Here we report that the accessory cell-derived T cell growth hormone interleukin-1 prevents T cell receptor-mediated thymocyte apoptosis by a mechanism that appears to involve protein kinase C activation. This effect may be relevant to the positive signaling that spares the appropriate precursors during the generation of functional T lymphocytes.

Original languageEnglish (US)
Pages (from-to)3009-3011
Number of pages3
JournalJournal of Biological Chemistry
Volume265
Issue number6
StatePublished - 1990
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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