Abstract
Secretion of goblet cell (GC) mucus occurs during immune reactions in the gut. As human macrophages produce a substance that induces mucus secretion from lung explants, we testedthe effect of macrophage-derived factor (s) on mucus secretion from intestinal explants. Fragments of mouse duodenum were incubated with macrophage culture supernatants and purified interleukin-1 (IL-1) preparations, and the amount of mucus released was estimated by an enzyme-linked lectin assay. Both the culture supernatants and the IL-1 preparations induced dose-and time-dependent mucus release. Lipopolysaccharide-induced culture fluids were shown to contain IL-1. Thus, stimulation of mucus secretion from GC can be added to the list of biological activities attributable to IL-1.
Original language | English (US) |
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Pages (from-to) | 364-365 |
Number of pages | 2 |
Journal | International archives of allergy and immunology |
Volume | 82 |
Issue number | 3-4 |
DOIs | |
State | Published - 1987 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology