Interleukin-1 induces mucus secretion from mouse intestinal explants

V. Han, J. Resau, R. Prendergast, A. Scott, David A. Levy

Research output: Contribution to journalArticle

Abstract

Secretion of goblet cell (GC) mucus occurs during immune reactions in the gut. As human macrophages produce a substance that induces mucus secretion from lung explants, we testedthe effect of macrophage-derived factor (s) on mucus secretion from intestinal explants. Fragments of mouse duodenum were incubated with macrophage culture supernatants and purified interleukin-1 (IL-1) preparations, and the amount of mucus released was estimated by an enzyme-linked lectin assay. Both the culture supernatants and the IL-1 preparations induced dose-and time-dependent mucus release. Lipopolysaccharide-induced culture fluids were shown to contain IL-1. Thus, stimulation of mucus secretion from GC can be added to the list of biological activities attributable to IL-1.

Original languageEnglish (US)
Pages (from-to)364-365
Number of pages2
JournalInternational archives of allergy and immunology
Volume82
Issue number3-4
DOIs
StatePublished - Jan 1 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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