TY - JOUR
T1 - Interleukin-1 immunoreactive innervation of the human hypothalamus
AU - Breder, Christopher D.
AU - Dinarello, Charles A.
AU - Saper, Clifford B.
PY - 1988
Y1 - 1988
N2 - Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1β was used to stain the human brain unmunohistochemically for IL-1beta; - like immunoreactive neural elements. IL-1β-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic nenromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.
AB - Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1β was used to stain the human brain unmunohistochemically for IL-1beta; - like immunoreactive neural elements. IL-1β-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic nenromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.
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U2 - 10.1126/science.3258444
DO - 10.1126/science.3258444
M3 - Article
C2 - 3258444
AN - SCOPUS:0023889666
VL - 240
SP - 321
EP - 324
JO - Science
JF - Science
SN - 0036-8075
IS - 4850
ER -