Interleukin-1 immunoreactive innervation of the human hypothalamus

Christopher D. Breder, Charles A. Dinarello, Clifford B. Saper

Research output: Contribution to journalArticlepeer-review


Interleukin-1 (IL-1) is a cytokine that mediates the acute phase reaction. Many of the actions of IL-1 involve direct effects on the central nervous system. However, IL-1 has not previously been identified as an intrinsic component within the brain, except in glial cells. An antiserum directed against human IL-1β was used to stain the human brain unmunohistochemically for IL-1beta; - like immunoreactive neural elements. IL-1β-immunoreactive fibers were found innervating the key endocrine and autonomic cell groups that control the central components of the acute phase reaction. These results indicate that IL-1 may be an intrinsic nenromodulator in central nervous system pathways that mediate various metabolic functions of the acute phase reaction, including the body temperature changes that produce the febrile response.

Original languageEnglish (US)
Pages (from-to)321-324
Number of pages4
Issue number4850
StatePublished - 1988

ASJC Scopus subject areas

  • General


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