Interleukin 1-driven secretion of interleukin 2 is highly temperature-dependent

H. M. Lederman, C. R. Brill, P. A. Murphy

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


To investigate the temperature dependence of T lymphocyte activation, we have examined the IL 1-induced secretion of IL 2 by the murine T lymphoma cell line LBRM-33-1A5. During 24-hr incubations, there are modest increases in IL 2 secretion as culture temperatures are increased from 33° to 37°C, but IL 2 secretion declines at higher temperatures. However, the kinetics of IL 2 release during the first 8 hr of culture are highly temperature-dependent. The rate of IL 2 release increases linearly with temperature over the range from 33° to 41°C, demonstrating temperature coefficients (Q10) > 70. In contrast, IL 2-promoted proliferation of a continuous T cell line is much less temperature-dependent with Q10 values of <4.0.

Original languageEnglish (US)
Pages (from-to)3808-3811
Number of pages4
JournalJournal of Immunology
Issue number11
StatePublished - 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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