Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in helicobacter pylori-infected peruvians

Sebastian Gehmert, Billie Velapatiño, Phabiola Herrera, Jaqueline Balqui, Livia Santivañez, Jaime Cok, Gloria Vargas, Juan Combe, Douglas J. Passaro, Sijin Wen, Frank Meyer, Douglas E. Berg, Robert H. Gilman

Research output: Contribution to journalArticle

Abstract

Particular alleles of the interleukin-1B (IL-1B) gene have been correlated with increased risk of atrophic gastritis and gastric cancer in the populations of East Asia and Europe. No such data exist from Peru, a developing country with a population genotypically different from others studied and with a high prevalence of Helicobacter pylori infection and gastric cancer. We conducted a case-control study comparing 334 hospitalized patients with atrophic gastritis or gastric cancer with 158 nonatrophic gastritis patients (controls). Conditional logistic regression analysis revealed that an increased risk of atrophic gastritis (odds ratio, 5.60) and gastric cancer (odds ratio, 2.36) was associated with the IL-1B-511 C allele. Our study is the first to establish this allele as a risk for these conditions. Given the high prevalence of H. pylori and recurrence rate after treatment, IL-1B-511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust H. pylori eradication efforts in Peru.

Original languageEnglish (US)
Pages (from-to)804-810
Number of pages7
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume81
Issue number5
DOIs
StatePublished - Nov 2009

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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    Gehmert, S., Velapatiño, B., Herrera, P., Balqui, J., Santivañez, L., Cok, J., Vargas, G., Combe, J., Passaro, D. J., Wen, S., Meyer, F., Berg, D. E., & Gilman, R. H. (2009). Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in helicobacter pylori-infected peruvians. American Journal of Tropical Medicine and Hygiene, 81(5), 804-810. https://doi.org/10.4269/ajtmh.2009.08-0494