Interleukin-1β promotes the induction of retinal autoimmune disease

Ruijuan Zhao, Hongyan Zhou, Jing Zhang, Xialin Liu, Shao Bo Su

Research output: Contribution to journalArticlepeer-review

Abstract

Interleukin-1β (IL-1β) is a potent proinflammatory cytokine that plays a critical role in initiating immunoinflammatory responses. In this study, we generated recombinant mouse IL-1β and anti-mouse IL-1β polyclonal antibodies to examine the effect of IL-1β on experimental autoimmune uveoretinitis (EAU), a mouse model for T cell-mediated eye autoimmune disease. Administration of mouse IL-1β by i.p. in the priming phase, but not in the effector phase, of immune response of EAU enhanced disease scores and its related immune responses including DTH, Ag-specific T cell proliferation and the production of IL-17 and IFN-γ. Furthermore, administration of anti-IL-1β antibody in the priming phase reduced EAU scores. These results suggest that IL-1β is an important mediator in the pathogenesis of autoimmune diseases such as uveitis.

Original languageEnglish (US)
Pages (from-to)285-292
Number of pages8
JournalInternational immunopharmacology
Volume22
Issue number2
DOIs
StatePublished - Oct 2014
Externally publishedYes

Keywords

  • Anti-IL-1β therapy
  • IL-1β
  • Priming phase
  • Uveitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Pharmacology

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