Interindividual heterogeneity in the hypoxic regulation of VEGF: Significance for the development of the coronary artery collateral circulation

Aylit Schultz, Lena Lavie, Irit Hochberg, Rafael Beyar, Tzachi Stone, Karl Skorecki, Peretz Lavie, Ariel Roguin, Andrew P. Levy

Research output: Contribution to journalArticle

Abstract

Background - The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity is not understood. In this study we test the hypothesis that failure to generate collateral vessels is associated with a failure to appropriately induce with hypoxia or ischemia the angiogenic factor, vascular endothelial growth factor (VEGF). Methods and Results - We correlated the VEGF response to hypoxia in the monocytes harvested from patients with coronary artery disease with the presence of collaterals visualized during routine angiography. We found that there was a highly significant difference in the hypoxic induction of VEGF in patients with no collaterals compared with patients with some collaterals (mean fold induction 1.9±0.2 versus 3.2±0.3, P

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalCirculation
Volume100
Issue number5
StatePublished - Aug 3 1999
Externally publishedYes

Keywords

  • Angiogenesis
  • Collateral circulation
  • Growth substances
  • Hypoxia
  • Ischemia

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Interindividual heterogeneity in the hypoxic regulation of VEGF: Significance for the development of the coronary artery collateral circulation'. Together they form a unique fingerprint.

  • Cite this

    Schultz, A., Lavie, L., Hochberg, I., Beyar, R., Stone, T., Skorecki, K., Lavie, P., Roguin, A., & Levy, A. P. (1999). Interindividual heterogeneity in the hypoxic regulation of VEGF: Significance for the development of the coronary artery collateral circulation. Circulation, 100(5), 547-552.