Abstract
Background - The coronary artery collateral circulation may be beneficial in protecting against myocardial ischemia and necrosis. However, there is a tremendous interindividual variability in the degree of new collateral formation in patients with coronary artery disease. The basis for this interindividual heterogeneity is not understood. In this study we test the hypothesis that failure to generate collateral vessels is associated with a failure to appropriately induce with hypoxia or ischemia the angiogenic factor, vascular endothelial growth factor (VEGF). Methods and Results - We correlated the VEGF response to hypoxia in the monocytes harvested from patients with coronary artery disease with the presence of collaterals visualized during routine angiography. We found that there was a highly significant difference in the hypoxic induction of VEGF in patients with no collaterals compared with patients with some collaterals (mean fold induction 1.9±0.2 versus 3.2±0.3, P
Original language | English (US) |
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Pages (from-to) | 547-552 |
Number of pages | 6 |
Journal | Circulation |
Volume | 100 |
Issue number | 5 |
State | Published - Aug 3 1999 |
Externally published | Yes |
Keywords
- Angiogenesis
- Collateral circulation
- Growth substances
- Hypoxia
- Ischemia
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine