Interferon regulatory factor 5, a novel mediator of cell cycle arrest and cell death

Betsy J. Barnes, Merrill J. Kellum, Karen E. Pinder, J. Augusto Frisancho, Paula M. Pitha

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously shown a critical role for IFN regulatory factor 5 (IRF-5) in the innate immune response to virus infection. For the first time, we now show that although IRF-5 is a direct target of p53, its cell cycle regulatory and proapoptotic effects are p53 independent. IRF-5 inhibits both in vitro and in vivo B-cell lymphoma tumor growth in the absence of wild-type p53. The molecular mechanism(s) of IRF-5-mediated growth inhibition is associated with a G2-M cell cycle arrest and modulation of growth regulatory and proapoptotic genes, including p21, Bak, DAP kinase 2, and Bax. Taken together, these data indicate that although IRF-5 is a downstream target of p53, its growth inhibitory and proapoptotic effects are independent of p53.

Original languageEnglish (US)
Pages (from-to)6424-6431
Number of pages8
JournalCancer Research
Volume63
Issue number19
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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