Interferon lambda 4 genotype is associated with jaundice and elevated aminotransferase levels during acute hepatitis C virus infection: Findings from the InC3 collaborative

on behalf of the InC3 Collaborative

Research output: Contribution to journalComment/debate

Abstract

Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016.

Original languageEnglish (US)
Article numberofw024
JournalOpen Forum Infectious Diseases
Volume3
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

Virus Diseases
Transaminases
Jaundice
Hepacivirus
Interferons
Genotype
Databases
Infection

Keywords

  • Acute infection
  • Alanine aminotransferase
  • Hepatitis C virus
  • IFNL4
  • Jaundice

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

Cite this

Interferon lambda 4 genotype is associated with jaundice and elevated aminotransferase levels during acute hepatitis C virus infection : Findings from the InC3 collaborative. / on behalf of the InC3 Collaborative.

In: Open Forum Infectious Diseases, Vol. 3, No. 1, ofw024, 01.01.2016.

Research output: Contribution to journalComment/debate

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abstract = "Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016.",
keywords = "Acute infection, Alanine aminotransferase, Hepatitis C virus, IFNL4, Jaundice",
author = "{on behalf of the InC3 Collaborative} and Kimberly Page and Ali Mirzazadeh and Rice, {Thomas M.} and Jason Grebely and Kim, {Arthur Y.} and Andrea Cox and Morris, {Meghan D.} and Margaret Hellard and Julie Bruneau and Shoukry, {Naglaa H.} and Dore, {Gregory J.} and Lisa Maher and Lloyd, {Andrew R.} and Georg Lauer and Maria Prins and McGovern, {Barbara H.}",
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AU - Mirzazadeh, Ali

AU - Rice, Thomas M.

AU - Grebely, Jason

AU - Kim, Arthur Y.

AU - Cox, Andrea

AU - Morris, Meghan D.

AU - Hellard, Margaret

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