@article{ef0c21df73234a639b09e0c49127a4d2,
title = "Interferon lambda 4 genotype is associated with jaundice and elevated aminotransferase levels during acute hepatitis C virus infection: Findings from the InC3 collaborative",
abstract = "Symptomatic acute HCV infection and interferon lambda 4 (IFNL4) genotypes are important predictors of spontaneous viral clearance. Using data from a multicohort database (Injecting Cohorts [InC3] Collaborative), we establish an independent association between host IFNL4 genotype and symptoms of acute hepatitis C virus infection. This association potentially explains the higher spontaneous clearance observed in some patients with symptomatic disease. Published by Oxford University Press on behalf of the Infectious Diseases Society of America 2016.",
keywords = "Acute infection, Alanine aminotransferase, Hepatitis C virus, IFNL4, Jaundice",
author = "{on behalf of the InC3 Collaborative} and Kimberly Page and Ali Mirzazadeh and Rice, {Thomas M.} and Jason Grebely and Kim, {Arthur Y.} and Cox, {Andrea L.} and Morris, {Meghan D.} and Margaret Hellard and Julie Bruneau and Shoukry, {Naglaa H.} and Dore, {Gregory J.} and Lisa Maher and Lloyd, {Andrew R.} and Georg Lauer and Maria Prins and McGovern, {Barbara H.}",
note = "Funding Information: Financial support. This work was funded by the National Institute on Drug Abuse (grants R01DA031056, R01DA033541, and R01DA1599901), the NIH (grants U19AI088791, U19AI066345, and R01DA016017), the National Institute of Allergy and Infectious Diseases (grant U19AI082630), the National Health and Medical Research Council of Australia (grants 222887, 630483, 331312, and 545891), the Victorian Operational Infrastructure Support Programme, and the Canadian Institutes of Health Research (grants MOP103138 and MOP106468).",
year = "2016",
month = jan,
day = "1",
doi = "10.1093/ofid/ofw024",
language = "English (US)",
volume = "3",
journal = "Open Forum Infectious Diseases",
issn = "2328-8957",
publisher = "Oxford University Press",
number = "1",
}