Interferon-γ promotes differentiation of neural progenitor cells via the JNK pathway

So Jung Kim, Tae Gen Son, Keunho Kim, Hee Ra Park, Mark P. Mattson, Jaewon Lee

Research output: Contribution to journalArticle

Abstract

It has been reported that interferon-γ (IFN-γ) facilitates differentiation of PC-12 cells and murine adult neural stem cells. Here we show that IFN-γ promotes the differentiation of C17.2 neural progenitor cells (NPC) into a neuronal phenotype characterized by neurite outgrowth and the expression of the neuronal marker protein β-III tubulin. IFN-γ induced an increase in the activity c-jun N-terminal kinase (JNK) without affecting activities of extracellular signal-regulated kinases (ERKs 1 and 2). An inhibitor of JNK blocked the ability of IFN-γ to promote differentiation of NPC into neurons, whereas an inhibitor of ERKs 1 and 2 did not. Our findings show that the pro-inflammatory cytokine, IFN-γ has the potential to stimulate neurogenesis, suggesting roles for this cytokine in development and repair of the nervous system.

Original languageEnglish (US)
Pages (from-to)1399-1406
Number of pages8
JournalNeurochemical Research
Volume32
Issue number8
DOIs
StatePublished - Aug 2007
Externally publishedYes

Fingerprint

Interferons
Phosphotransferases
Stem Cells
Cytokines
Adult Stem Cells
Mitogen-Activated Protein Kinase 3
Neural Stem Cells
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinase 1
Extracellular Signal-Regulated MAP Kinases
Neurogenesis
Neurology
Tubulin
Stem cells
Nervous System
Neurons
Repair
Phenotype
Proteins

Keywords

  • ERK
  • Inflammation
  • Neurite outgrowth
  • Neurogenesis

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry

Cite this

Kim, S. J., Son, T. G., Kim, K., Park, H. R., Mattson, M. P., & Lee, J. (2007). Interferon-γ promotes differentiation of neural progenitor cells via the JNK pathway. Neurochemical Research, 32(8), 1399-1406. https://doi.org/10.1007/s11064-007-9323-z

Interferon-γ promotes differentiation of neural progenitor cells via the JNK pathway. / Kim, So Jung; Son, Tae Gen; Kim, Keunho; Park, Hee Ra; Mattson, Mark P.; Lee, Jaewon.

In: Neurochemical Research, Vol. 32, No. 8, 08.2007, p. 1399-1406.

Research output: Contribution to journalArticle

Kim, SJ, Son, TG, Kim, K, Park, HR, Mattson, MP & Lee, J 2007, 'Interferon-γ promotes differentiation of neural progenitor cells via the JNK pathway', Neurochemical Research, vol. 32, no. 8, pp. 1399-1406. https://doi.org/10.1007/s11064-007-9323-z
Kim, So Jung ; Son, Tae Gen ; Kim, Keunho ; Park, Hee Ra ; Mattson, Mark P. ; Lee, Jaewon. / Interferon-γ promotes differentiation of neural progenitor cells via the JNK pathway. In: Neurochemical Research. 2007 ; Vol. 32, No. 8. pp. 1399-1406.
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