Interferon γ-induced protein10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection: Implications for the innate immune response

Jennifer C. Lin, François Habersetzer, Maribel Rodriguez-Torres, Nezam Afdhal, Eric J. Lawitz, Matthew S. Paulson, Yanni Zhu, Gangadharan Mani Subramanian, John G. McHutchison, Mark Sulkowski, David L. Wyles, Robert T. Schooley

Research output: Contribution to journalArticle

Abstract

We measured interferon γ-induced protein 10 (IP-10) levels in 428 patients at baseline, week 1, and week 2 of all-oral treatment for hepatitis C virus (HCV) infection. An increased baseline IP-10 level was associated with a T allele in the IL28B gene, an increased alanine aminotransferase level in treatment-naive but not experienced patients, and an increased body mass index. At week 1, the mean decline in plasma IP-10 levels was the same in treatment-naive and treatment-experienced patients (-49%), whereas during week 2 the mean decline in IP-10 levels in treatment-naive patients (-14%) was significantly larger than in treatmentexperienced patients (-2%; P =.0176). IP-10 thus may be a surrogate marker of the rate of intracellular viral replication complex decay.

Original languageEnglish (US)
Pages (from-to)1881-1885
Number of pages5
JournalJournal of Infectious Diseases
Volume210
Issue number12
DOIs
StatePublished - 2014

Keywords

  • Direct-acting antiviral therapy
  • Hepatitis C
  • IP-10
  • Innate immunity

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Lin, J. C., Habersetzer, F., Rodriguez-Torres, M., Afdhal, N., Lawitz, E. J., Paulson, M. S., Zhu, Y., Subramanian, G. M., McHutchison, J. G., Sulkowski, M., Wyles, D. L., & Schooley, R. T. (2014). Interferon γ-induced protein10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection: Implications for the innate immune response. Journal of Infectious Diseases, 210(12), 1881-1885. https://doi.org/10.1093/infdis/jiu325