TY - JOUR
T1 - Interferon γ-induced protein10 kinetics in treatment-naive versus treatment-experienced patients receiving interferon-free therapy for hepatitis C virus infection
T2 - Implications for the innate immune response
AU - Lin, Jennifer C.
AU - Habersetzer, François
AU - Rodriguez-Torres, Maribel
AU - Afdhal, Nezam
AU - Lawitz, Eric J.
AU - Paulson, Matthew S.
AU - Zhu, Yanni
AU - Subramanian, Gangadharan Mani
AU - McHutchison, John G.
AU - Sulkowski, Mark
AU - Wyles, David L.
AU - Schooley, Robert T.
N1 - Publisher Copyright:
© The Author 2014.
PY - 2014/12
Y1 - 2014/12
N2 - We measured interferon γ-induced protein 10 (IP-10) levels in 428 patients at baseline, week 1, and week 2 of all-oral treatment for hepatitis C virus (HCV) infection. An increased baseline IP-10 level was associated with a T allele in the IL28B gene, an increased alanine aminotransferase level in treatment-naive but not experienced patients, and an increased body mass index. At week 1, the mean decline in plasma IP-10 levels was the same in treatment-naive and treatment-experienced patients (-49%), whereas during week 2 the mean decline in IP-10 levels in treatment-naive patients (-14%) was significantly larger than in treatmentexperienced patients (-2%; P =.0176). IP-10 thus may be a surrogate marker of the rate of intracellular viral replication complex decay.
AB - We measured interferon γ-induced protein 10 (IP-10) levels in 428 patients at baseline, week 1, and week 2 of all-oral treatment for hepatitis C virus (HCV) infection. An increased baseline IP-10 level was associated with a T allele in the IL28B gene, an increased alanine aminotransferase level in treatment-naive but not experienced patients, and an increased body mass index. At week 1, the mean decline in plasma IP-10 levels was the same in treatment-naive and treatment-experienced patients (-49%), whereas during week 2 the mean decline in IP-10 levels in treatment-naive patients (-14%) was significantly larger than in treatmentexperienced patients (-2%; P =.0176). IP-10 thus may be a surrogate marker of the rate of intracellular viral replication complex decay.
KW - Direct-acting antiviral therapy
KW - Hepatitis C
KW - IP-10
KW - Innate immunity
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U2 - 10.1093/infdis/jiu325
DO - 10.1093/infdis/jiu325
M3 - Article
C2 - 24907384
AN - SCOPUS:84928939760
SN - 0022-1899
VL - 210
SP - 1881
EP - 1885
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 12
ER -