Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children

Mark J. Abzug, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

Abstract

A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-γ and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-γ, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.

Original languageEnglish (US)
Pages (from-to)769-773
Number of pages5
JournalPediatric Infectious Disease Journal
Volume23
Issue number8
DOIs
StatePublished - Aug 2004

Keywords

  • Children
  • Colony-stimulating factor
  • Cytokines
  • Fungal infection
  • Interferon-γ

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Microbiology (medical)
  • Infectious Diseases

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