Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children

Mark J. Abzug; Thomas J. Walsh

doi:10.1097/01.inf.0000134314.65398.bf

Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children

Mark J. Abzug, Thomas J. Walsh

Research output: Contribution to journal › Article › peer-review

76 Scopus citations

Abstract

A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-γ and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-γ, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.

Original language	English (US)
Pages (from-to)	769-773
Number of pages	5
Journal	Pediatric Infectious Disease Journal
Volume	23
Issue number	8
DOIs	https://doi.org/10.1097/01.inf.0000134314.65398.bf
State	Published - Aug 2004
Externally published	Yes

Keywords

Children
Colony-stimulating factor
Cytokines
Fungal infection
Interferon-γ

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Microbiology (medical)
Infectious Diseases

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10.1097/01.inf.0000134314.65398.bf

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abstract = "A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-γ and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-γ, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.",

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AB - A human immunodeficiency virus-infected boy with Scedosporium apiospermum otomastoiditis and a girl with diabetes mellitus and Mucor sinusitis and orbital cellulitis had life-threatening disease progression despite antifungal treatment. Interferon-γ and granulocyte-macrophage or granulocyte colony-stimulating factor were added, with good functional outcome in both children. Adjunctive therapy with interferon-γ, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor can be considered for refractory invasive fungal infections.

KW - Children

KW - Colony-stimulating factor

KW - Cytokines

KW - Fungal infection

KW - Interferon-γ

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Interferon-γ and colony-stimulating factors as adjuvant therapy for refractory fungal infections in children

Abstract

Keywords

ASJC Scopus subject areas

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