Interference of immune globulin with measles and rubella immunization

George R. Siber, Barbara G. Werner, Neal A. Halsey, Raymond Reid, Janné Almeido-Hill, Steven C. Garrett, Claudette Thompson, Mathuram Santosham

Research output: Contribution to journalArticlepeer-review


Passively acquired antibody may interfere with the active antibody response to live viral vaccines such as measles and rubella. To evaluate the duration of this inhibitory effect, we measured the measles and rubella antibody responses of Apache children immunized with measies, mumps, and rubella vaccine at varying intervals after administration of an immune globulin termed bacterial polysaccharide immune globulin (BPIG). This specific immune globulin contained measles and rubella antibody titers similar to those in standard intramuscularly and intravenously administered immune globulins. Antibody responses to measies vaccine were inhibited for up to 5 months after a BPIG dose of 80 mg IgG perkllogram of body weight, but responses to rubella vaccine were inhibited for only 2 months. Most children who had a decreased measles antibody response to primary measles, mumps, and rubella immunization given 11/2 to 4 months after BPIG administration responded to a booster immunization given 6 months after their last BPIG dose. We conclude that high doses of immune globulin (>10 mg/kg) may inhibit the antibody response to measles for more than 3 months. We propose that the interval between administration of immune globulin and measles and rubella immunization be adjusted on the basis of the dose of immune globulin.

Original languageEnglish (US)
Pages (from-to)204-211
Number of pages8
JournalJournal of Pediatrics
Issue number2
StatePublished - 1993

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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