Interdependent roles of nitric oxide (NO) and 5-lipoxygenase (5-LO) during accelerated nephrotoxic serum nephritis (ants) in 5-lo gene deleted mice (5-LO-/-)

K. A. Manger, E. Cruel, A. Fogo, C. Funk, K. F. Badr

Research output: Contribution to journalArticlepeer-review

Abstract

While investigating the protective role of NO during nephritis (FASEB J, 9(3)), we found that inhibition of NO in human monocyte incubates resulted in a marked increase in mRNA levels for 5-LO (which catalyzes the formation of leukotrienes, proinflammatory eicosanoids). This led us to investigate the effects of nephritis in 5-LO-/- and wild type mice, and mRNA expression of inducible.NO synthase (iNOS). aNTS was induced by pre-immunization with sheep IgG+CFA ip, followed by iv sheep anti-rat GBM 48 hrs prior to study. Data for the following groups is reported; Wild; 5-LO-/-; Wild + aNTS; and 5LO-/- + aNTS, respectively. n=5 all groups.p

Original languageEnglish (US)
JournalFASEB Journal
Volume10
Issue number3
StatePublished - 1996
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences (miscellaneous)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Fingerprint

Dive into the research topics of 'Interdependent roles of nitric oxide (NO) and 5-lipoxygenase (5-LO) during accelerated nephrotoxic serum nephritis (ants) in 5-lo gene deleted mice (5-LO-/-)'. Together they form a unique fingerprint.

Cite this