Interactions of the human immunodeficiency virus with astrocytes

Avindra Nath; Christopher Power; Jonathan D. Geiger

doi:10.1007/BF02173999

Interactions of the human immunodeficiency virus with astrocytes

Avindra Nath, Christopher Power, Jonathan D. Geiger

School of Medicine

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Infection with the human immunodeficiency virus type 1 (HIV-1) can cause a dementing illness. Astrocytes, the most numerous cells within the central nervous system, can be infected with HIV-1. These cells are infected by predominantly lymphotropic strains of HIV-1. The mode of infection does not involve CD4 or galactocerebroside C and is, most likely, due to a unique binding-site protein located on the surface of astrocytes. The virus produces low levels of infection. Astrocytic function is significantly altered by viral proteins and nonviral products released by other infected cells. Future therapeutic developments for treating HIV-1 infection will need to take into account the unique mechanisms of interaction of HIV-1 with astrocytes. This review discusses astrocyte involvement in the pathogenesis of the HIV-1 cognitive motor complex.

Original language	English (US)
Pages (from-to)	30-42
Number of pages	13
Journal	Perspectives in Drug Discovery and Design
Volume	5
DOIs	https://doi.org/10.1007/BF02173999
State	Published - Jan 1 1996

ASJC Scopus subject areas

Pharmacology
Drug Discovery
Organic Chemistry

Access to Document

10.1007/BF02173999

Cite this

@article{092e5352f171446bae5b72ab68b60d71,

title = "Interactions of the human immunodeficiency virus with astrocytes",

abstract = "Infection with the human immunodeficiency virus type 1 (HIV-1) can cause a dementing illness. Astrocytes, the most numerous cells within the central nervous system, can be infected with HIV-1. These cells are infected by predominantly lymphotropic strains of HIV-1. The mode of infection does not involve CD4 or galactocerebroside C and is, most likely, due to a unique binding-site protein located on the surface of astrocytes. The virus produces low levels of infection. Astrocytic function is significantly altered by viral proteins and nonviral products released by other infected cells. Future therapeutic developments for treating HIV-1 infection will need to take into account the unique mechanisms of interaction of HIV-1 with astrocytes. This review discusses astrocyte involvement in the pathogenesis of the HIV-1 cognitive motor complex.",

author = "Avindra Nath and Christopher Power and Geiger, {Jonathan D.}",

year = "1996",

month = jan,

day = "1",

doi = "10.1007/BF02173999",

language = "English (US)",

volume = "5",

pages = "30--42",

journal = "Perspectives in Drug Discovery and Design",

issn = "0928-2866",

publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Interactions of the human immunodeficiency virus with astrocytes

AU - Nath, Avindra

AU - Power, Christopher

AU - Geiger, Jonathan D.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Infection with the human immunodeficiency virus type 1 (HIV-1) can cause a dementing illness. Astrocytes, the most numerous cells within the central nervous system, can be infected with HIV-1. These cells are infected by predominantly lymphotropic strains of HIV-1. The mode of infection does not involve CD4 or galactocerebroside C and is, most likely, due to a unique binding-site protein located on the surface of astrocytes. The virus produces low levels of infection. Astrocytic function is significantly altered by viral proteins and nonviral products released by other infected cells. Future therapeutic developments for treating HIV-1 infection will need to take into account the unique mechanisms of interaction of HIV-1 with astrocytes. This review discusses astrocyte involvement in the pathogenesis of the HIV-1 cognitive motor complex.

AB - Infection with the human immunodeficiency virus type 1 (HIV-1) can cause a dementing illness. Astrocytes, the most numerous cells within the central nervous system, can be infected with HIV-1. These cells are infected by predominantly lymphotropic strains of HIV-1. The mode of infection does not involve CD4 or galactocerebroside C and is, most likely, due to a unique binding-site protein located on the surface of astrocytes. The virus produces low levels of infection. Astrocytic function is significantly altered by viral proteins and nonviral products released by other infected cells. Future therapeutic developments for treating HIV-1 infection will need to take into account the unique mechanisms of interaction of HIV-1 with astrocytes. This review discusses astrocyte involvement in the pathogenesis of the HIV-1 cognitive motor complex.

UR - http://www.scopus.com/inward/record.url?scp=0343894107&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343894107&partnerID=8YFLogxK

U2 - 10.1007/BF02173999

DO - 10.1007/BF02173999

M3 - Article

AN - SCOPUS:0343894107

SN - 0928-2866

VL - 5

SP - 30

EP - 42

JO - Perspectives in Drug Discovery and Design

JF - Perspectives in Drug Discovery and Design

ER -

Interactions of the human immunodeficiency virus with astrocytes

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this